Application of virtual screening technology in the development of melanin generation inhibitors
With the development of economy and society,great business opportunities have emerged in the skin whitening and anti-spot industry.Melanin content and its distribution are considered to be important factors affecting skin color.Tyrosinase(TYR)is a key rate-limiting enzyme in the regulation of melanin content.Microphthalmia-associated transcription factor(MITF)is a major regulator of melanocytes and plays a key role in the differentiation and proliferation of melanocytes.A large number of studies have shown that by reducing the activity or stability of TYR,or interfering with the normal transcription of MITF,various skin problems caused by abnormal melanin production can be prevented or alleviated.Virtual screening has the advantages of low cost and high efficiency.This technology has a good application prospect in screening melanin synthesis inhibitors.In this paper,the synthesis and regulation of melanin were summarized,and the application progress of virtual screening technology in the development of melanin production inhibitors was reviewed,which provided a reference for exploring the lead compounds of melanin production inhibitors.
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