Simultaneous determination of sulfonamides and quinolones antibiotics in cosmetics by high-performance liquid chromatography-tandem mass spectrometry
A method for simultaneous determination of 53 anti-infective drugs such as quinolones and sulfonamides in cosmetics was established by high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).The samples were dispersed with saturated sodium chloride,extracted by ultrasound with 1%acetonitrile formate solution,and centrifuged.0.1%Formic acid aqueous solution(containing 1 mmol/L ammonium acetate)and 0.1%formic acid methanol solution were chose as mobile phase,gradient elution was used,and electrospray ion source,positive ion multi-reaction monitoring mode(MRM)were used for determination with quantitative external standard method.The results show that the linear fitting of the 53 banned raw materials is good,with the correlation coefficient greater than 0.991 0,and the detection limit of 0.01-0.1 μg/g.The average recovery rates of sulfonamides and quinolones are 80.84%to 115.09%at low,medium,and high spiked mass concentrations.Among the 100 batches of samples screened,1 batch is detected to contain sulfamethoxazole.The method has good sensitivity,selectivity and accuracy,and can be used for the determination of 53 anti-infective drugs in cosmetics.
high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)sulfonamidesquinolones
万方数据
维普
