Study on the silicon dioxide encapsulation for the enhancement of vitamin C stability
To improve the stability of vitamin C(Vc)in cosmetics,Vc was coated with silica dioxide(Vc@SiO2),modified by silane(Vc@s-SiO2)and dispersed in decanoyl/octanoyl-glycerides(GTCC)oil phase system.The experimental results show that the encapsulation rate and drug loading rate are 68.2%and 13.6%,respectively,when Vc is encapsulated into silica dioxide.After modification,the surface of Vc@s-SiO2 is hydrophobic and the contact angle increases from 33.6° to 130.7°.When Vc is maintained at 50℃or exposed to ultraviolet light,Vc@s-SiO2 exhibits an increase in antioxidant activity by 11.4 times and 27.7 times,respectively,compared to free Vc.This study reveals that silica dioxide coated Vc and dispersed in GTCC can isolate the adverse factors such as water oxygen,reduce the activity loss and improve the stability of Vc.
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