Validation of the efficacy of a group of compositions for ameliorating acne problems
To verify the inhibitory ability of the compositions on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems,the ability of the compositions to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining.And then 60 effective volunteers were selected for the efficacy measurement of the topical acne elimination compositions+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers'facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the compositions could inhibit the formation of P.acnes biofilm,would not completely kill P.acnes and would not disrupt the micro-ecological balance of the skin.The concentration of 3%and 5%anti-acne compositions could reduce the biofilm of P.acnes by 61.3%and 61.6%,respectively.After 4 weeks of continuous use,the area of acne lesions of the samples with 5%anti-acne compositions decreased by 54.61%and the skin colour a* values of acne lesions decreased by 13.74%compared with the area of acne lesions before the use of the compositions.The subjects'self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The anti-acne compositions can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.
biofilmpropionibacterium acnesanti-acneefficacy test
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