首页|类器官模型在乳及乳制品中的应用研究进展

类器官模型在乳及乳制品中的应用研究进展

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类器官由成体干细胞或多能干细胞在体外分化而来,可在细胞类型、空间结构及生理功能上实现对体内器官的模拟.目前,类器官模型已经在药物研发、精准医疗等领域得到广泛应用,并且已经应用于食品安全领域.本文综述类器官的发展历程、分类、构建及其在乳及乳制品代谢组学、营养成分功能评价及肠道保护作用研究等方面的应用,并总结类器官模型存在的问题,展望类器官模型在乳及乳制品中的应用前景,以期为类器官模型在食品安全、营养等领域的进一步应用提供参考.
Advances in Application of Organoid Models in Milk and Dairy Products
Organoids are derived from adult or pluripotent stem cells through in vitro differentiation,which can recapitulate the cellular diversity,spatial organization,and physiological functions of in vivo organs or tissues.Organoid models have been widely used in drug development,precision medicine and other fields,and have begun to be applied in the field of food safety.This paper briefly introduces the development history,classification and construction of organoids and their application in the metabolomics,nutritional and functional evaluation of milk and dairy products and research on their roles in intestinal protection.It also summarizes problems existing in the construction of organoid models and discusses future prospects for their application in milk and dairy products in order to provide a reference for further application of organoid models in various fields including food safety and nutrition.

organoidsmilk and dairy productsmetabolomicsfunctional evaluationintestinal protection

范素芳、王旭、张岩

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河北省食品检验研究院,河北省食品安全重点实验室,国家市场监督管理总局重点实验室(特殊食品监管技术),特殊食品安全与健康河北省工程研究中心,河北 石家庄 050227

河北医科大学法医学院,河北省法医学重点实验室,河北 石家庄 050017

类器官 乳及乳制品 代谢组学 功能评价 肠道保护

国家市场监督管理总局技术保障专项国家市场监督管理总局技术保障专项特殊食品监管技术重点实验室建设项目

2023YJ222023YJ372021JG46

2024

乳业科学与技术
上海奶业行业协会 光明乳业股分有限公司技术中心 上海市奶牛研究所 上海乳品培训研究中心

乳业科学与技术

CSTPCD
影响因子:0.619
ISSN:1671-5187
年,卷(期):2024.47(5)