瑞舒伐他汀钙辅助氯吡格雷治疗急性冠脉综合征的临床疗效
Clinical Efficacy of Rosuvastatin Calcium Assisted Clopidogrel in the Treatment of Acute Coronary Syndrome
刘虹 1王迪 2刘娜1
作者信息
- 1. 睢县中医院药学部,商丘 476900
- 2. 睢县中医院内七科,商丘 476900
- 折叠
摘要
目的:观察瑞舒伐他汀钙辅助氯吡格雷治疗急性冠脉综合征(ACS)的临床疗效.方法:选取 2020 年 5 月至 2022 年 12 月于本院心内科就诊治疗的ACS患者 107 例作为研究对象,根据药物方案不同分为实验组(n =55,瑞舒伐他汀钙辅助氯吡格雷治疗)和对照组(n =52,氯吡格雷治疗).比较两组总疗效、炎症反应与血管内皮功能[超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-1、内皮素(ET)-1 及一氧化氮(NO)]、心血管不良事件(MACE)发生率及用药安全性.结果:实验组总疗效率高于对照组,差异有统计学意义(P＜0.05).实验组血清hs-CRP、IL-1及ET-1 均显著低于对照组,NO 水平高于对照组,差异均有统计学意义(P＜0.05).实验组 MACE 总发生率(3.62%)显著低于对照组(17.30%),差异具有统计学意义(P＜0.05).两组不良反应比较差异无统计学意义(P＞0.05).结论:瑞舒伐他汀钙辅助氯吡格雷治疗ACS可提高其疗效,减少炎症因子生成,改善血管内皮功能,降低MACE发生率,且用药安全性高.
Abstract
Objective:To observe the clinical efficacy of rosuvastatin calcium assisted clopidogrel in the treatment of acute coronary syndrome(ACS).Methods:A total of 107 patients with ACS who were treated in the cardiology department of our hospital from May 2020 to December 2022 were selected,and were divided into the experimental group(n =55,rosuvastatin calcium-assisted clopidogrel treatment)and the control group(n =52,clopidogrel treatment)according to different drug regimens.The overall efficacy,inflammatory response and vascular endothelial function[hypersensitive C-reactive protein(hs-CRP),interleukin(IL)-1,endothelin(ET)-1and nitric oxide(NO)],major adverse cardiovascular events(MACE)and drug safety were compared between the two groups.Results:The total curative effect rate of experimental group was higher than that of reference group(P＜0.05).Serum hs-CRP,IL-1 and ET-1 in test group were lower than those in reference group,and serum NO level in test group was higher than that in reference group,and the differences were statistically significant(P＜0.05).The total incidence of MACE in test group(3.62%)was lower than that in reference group(17.30%),and the difference was statistically significant(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion:Rosuvastatin calcium assisted clopidogrel in the treatment of ACS can improve its efficacy,reduce the production of inflammatory factors,improve vascular endothelial function,and reduce the incidence of MACE,with high safety.
关键词
瑞舒伐他汀钙/氯吡格雷/急性冠脉综合征/临床疗效Key words
Rosuvastatin calcium/Clopidogrel/Acute coronary syndrome/Clinical effect引用本文复制引用
出版年
2024
NETL
NSTL
万方数据