Effect of Feed Restriction in Cold Season on Yak Liver Metabolism
[Objective]This study aimed to analyze the mechanism of starvation on yak body metabolism,this experiment insufficient nutrient intake in the cold season of grazing yaks was simulated by restricting feeding,using metabolomics research methods,and the liver metabolic profile of the yak was studied us-ing the 1H-NMR platform.[Method]Eight healthy Maiwa male yaks with similar weight(245 kg±8.75 kg)were randomly divided into 2 groups(group C and E respectively),with four yaks in each group.Group C yaks fed 2.5%of their body weight daily(dry matter basis),group E fed 50%of group C.The to-tal 8 yaks were slaughtered for the liver samples after 60 days of feeding.[Result]Approximately,46 small metabolites were detected in yak liver by 1H-NMR technology,of which Glutamate,Lactate,sn-Glycero-3-phosphocholine,Glycine,Urea,Glucose had a significant difference,were enriched in 8 metabolic pathways such as D-Glutamine and D-glutamate metabolism,Alanine,aspaitate and gluta-mate metabolism,taurine and hypotaurine metabolism,beta-Alanine metabolism.[Conclusion]In con-clusion,starvation caused by cold season has significant effect on glucose and lipid metabolism,urea ni-trogen metabolism,body immunity and anti-oxidative ability in yak.It is suggested that the effective supplementation of feeds in the cold season on the yak can improve glucose,lipid and nitrogen metabo-lism,and enhance the body immunity and antioxidative capacity,and finally decrease the morbidity and mortality.
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