Effect of lenvatinib assisted TACE sequential radiofrequency ablation on Hepatitis B complicated with advanced liver cancer
Objective:To study the efficacy of lenvatinib combined with hepatic artery catheter chemoembolization(TACE)sequential radiofrequency ablation in the treatment of advanced hepatocellular carcinoma combined with hepatitis B and its effect on pro-angiogenic factors.Methods:Sixty-six patients with advanced hepatocellular carcinoma combined with hepatitis B admitted to our hospital from April 2019 to April 2022 were studied,and the patients were divided into group B and group A using the random number table method,with 33 patients in each group.Group B was treated with TACE sequential radiofrequency ablation,and group A was treated with lenvatinib combined with TACE sequential radiofrequency ablation.The clinical efficacy,liver function indexes(alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)),serum pro-angiogenic factors(basic fibroblast growth factor(bFGF),hypoxia-inducible factor 1α(HIF-1α),vascular endothelial growth factor(VEGF),angiopoietin-2(Ang-2))levels,serum apoptotic factors(cysteine aspartate protease 8(Caspase8),soluble apoptotic factor(sFas))levels,and adverse reactions before and after 6 weeks of treatment were compared between the two groups.Results:The total clinical effective rate in group A was 81.82%(27/33)higher than that in group B,57.58%(19/33)(P<0.05);the levels of ALT,AST and TBIL in group A were lower than those in group B after 6 weeks of treatment(P<0.05).Serum bFGF,HIF-1α,VEGF,and Ang-2 levels in group A were lower than those in group B after 6 weeks of treatment(P<0.05);serum Caspase8 levels in group A were higher than those in group B and sFas levels were lower than those in group B after 6 weeks of treatment(P<0.05);the overall incidence of adverse reactions in group A was 18.18%(6/33)compared with 12.12%(4/33)in group B.The difference was not statistically significant(P>0.05).Conclusion:Lenvatinib combined with TACE sequential radiofrequency ablation can further enhance the efficacy,improve liver function,and regulate the levels of vascular endothelial growth factor and apoptotic factor in patients with advanced hepatocellular carcinoma combined with hepatitis B.It is safe and feasible.
LenvatinibHepatic artery catheter chemoembolizationSequential radiofrequency ablationHepatitis B combined with advanced hepatocellular carcinoma
万方数据
维普
