Effect of sevoflurane combined intravenous inhalational anesthesia on anesthesia quality and cognitive function in patients with femoral neck fractures performed with hip arthroplasty
Objective:To analyze the clinical advantages of sevoflurane combined intravenous inhalational anesthesia in patients with femoral neck fracture(FNF)treated by hip arthroplasty(HA)and to provide reference for the selection of anesthesia modality.Methods:98 patients with FNF performed HA in our hospital from August 2020 to August 2021 were selected and divided randomly.into two groups,with 49 patients in each group.The all-voucher group was anesthetized with all-voucher intravenous anesthesia;the composite group was anesthetized with sevoflurane combined intravenous inhalational anesthesia.The anesthesia quality,the mean arterial pressure(MAP)and saturation of blood oxygen(SPO2)before anesthesia(T0)/10 min after anesthesia(T1)/the time of skin incision(T2)/the end of surgery(T3),Myelin basic protein(MBP),nerve growth factor-β(NGF-β),and S100β(S100β)levels and the cognitive function(Montreal Cognitive Assessment,MOCA)before and after surgery were compared between the two groups.Results:Time to awaken,time to spontaneous breathing,time to speech response and time to recovery of orientation in the composite group were shorter than those in all-voucher group(P<0.05);compared to T0,MAP and SPO2 were higher in both groups at T1 and T2,and the indexes in the composite group were lower than those in the full voucher group(P<0.05),and MAP in the composite group was lower than that in the full voucher group at T3(P<0.05).after surgery,the levels of NGF-β were lower in both groups;and the levels of NGF-β in the composite group were lower than those in the full voucher group;the levels of MBP and S100β were higher in both groups;and their levels in the composite group were lower than those in the full voucher group(P<0.05);at 2 h,6 h and 24 h after surgery,MOCA scores in the composite group were higher than those in the full voucher group(P<0.05).Conclusion:Sevoflurane combined intravenous inhalational anesthesia used in FNF performed HA could enhance the quality of anesthesia,stabilize the hemodynamics,reduce neurological impairment,improve cognitive function.
Femoral neck fractureSevofluraneCognitive function
万方数据
维普
