Effects of epalrestat,mecobalamine combined with α-lipoic acid on nerve repair and antioxidant stress in elderly patients with diabetic peripheral neuropathy
Objective:To explore the effects of α-lipoic acid in the treatment of Diabetic Peripheral Neuropathy(DPN)in elderly patients and its effects on the resistance to oxidative stress and neuropathy.Methods:A total of 106 elderly patients with DPN admitted to our department from October 2020 to October 2022 were selected as research objects,and randomly divided into study group and control group,with 53 cases in each group.Control group was treated with epalrestat and mecobalamine.The study group was supplemented with α-lipoic acid adjuvant therapy,all of which lasted for 4 weeks.The nerve repair effect,nerve conduction velocity,antioxidant stress ability,clinical efficacy and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was significantly higher than that of the control group(P<0.05).At the end of 4w,the nerve repair effect of the patients was as follows:the transverse and longitudinal diameters of the radial nerve,ulnar nerve and median nerve were decreased compared with that of the control group.Nerve conduction velocity:median nerve,common peroneal nerve and posterior tibial nerve sensory nerve conduction velocity and motor conduction velocity were all faster than that of the control group.The total antioxidant capacity and serum level of superoxide dismutase were higher than those of control group,but malondialdehyde was lower than that of control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:α-lipoic acid adjuvant therapy can effectively improve nerve conduction velocity,nerve repair and antioxidant stress ability in elderly patients with DPN,with less and effective adverse reactions.
diabetic peripheral neuropathyAlpha-lipoic acidEpalrestatNerve repairResistance to oxidative stress
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