四川生理科学杂志2024，Vol.46Issue(1) ：68-70.

阿仑膦酸钠辅助碳酸钙D3 片对老年2型糖尿病合并骨质疏松患者的临床效果观察

Clinical observation of alendronate sodium assisted calcium carbonate D3 tablets in elderly patients with type 2 diabetes mellitus complicated with osteoporosis

单帅 冯培红 王欢欢
四川生理科学杂志2024，Vol.46Issue(1) ：68-70.
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阿仑膦酸钠辅助碳酸钙D3 片对老年2型糖尿病合并骨质疏松患者的临床效果观察

Clinical observation of alendronate sodium assisted calcium carbonate D3 tablets in elderly patients with type 2 diabetes mellitus complicated with osteoporosis

单帅 1冯培红 1王欢欢1
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作者信息

  • 1. 郑州大学附属郑州中心医院内分泌科,河南 郑州 450000
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摘要

目的:探讨2型糖尿病合并骨质疏松老年患者应用阿仑膦酸钠辅助碳酸钙D3片治疗的临床效果.方法:抽签法将 2021 年 2 月至 2022 年 2 月期间我科老年 2 型糖尿病合并骨质疏松患者 95 例分为两组,均采用控制血糖等基础治疗外,对照组47例口服碳酸钙D3,观察组48例口服碳酸钙D3 加阿仑膦酸钠,持续治疗1 y后,采用临床疗效、血清激素水平、骨密度、骨代谢指标及药物安全性评价两组治疗临床效果.结果:观察组总有效率93.75%(45/48)高于对照组的总有效率 78.72%(37/47),与治疗前比较,两组 25-羟基维生素D、Wards三角区、股骨粗隆、股骨颈、腰椎L1～4 部位骨密度均明显增加,甲状旁腺素、β-胶原片段、骨钙素及骨碱性磷酸酶水平均明显下降(P＜0.05),其中观察组变化值均较对照组更为显著,差异有统计学意义(P＜0.05).两组不良反应无明显差异(P＞0.05).结论:2型糖尿病合并骨质疏松老年患者应用阿仑膦酸钠辅助碳酸钙D3片口服治疗,可有效调节其血清激素水平、骨密度和骨代谢指标,安全且疗效较好.

Abstract

Objective:To investigate the clinical effect of alendronate sodium and calcium carbonate D3 tablets in the treatment of elderly patients with type 2 diabetes mellitus complicated with osteoporosis.Method:Ninety-five elderly patients with type 2 diabetes mellitus complicated with osteoporosis in our department were divided into two groups from February 2021 to February 2022.Except for basic treatment such as blood sugar control,in the control group 47 patients received oral calcium carbonate D3,and 48 patients in the observation group received oral calcium carbonate D3 plus alendronate sodium.After continuous treatment for 1year,Clinical efficacy,serum hormone levels,bone mineral density,bone metabolism indexes and drug safety were used to evaluate the clinical efficacy of the two groups.Results:The total effective rate of 93.75%(45/48)in the observation group was higher than that of 78.72%(37/47)in the control group.Compared with before treatment,the bone density of 25-hydroxyvitamin D,Wards triangle,femoral trochote,femoral neck and lumbar vertebrol in each group increased significantly.The levels of parathyroid hormone,β-collagen fragment,osteocalcin,and bone alkaline phosphatase were significantly decreased(P<0.05),and the change values in observation group were higher than those in control group,with statistical significance(P<0.05).There was no significant difference in ADR between the two groups(P>0.05).Conclusions:Calcium carbonate D3 tablets combined with alendronate sodium can effectively regulate serum hormone levels,bone mineral density and bone metabolism indexes in elderly patients with type 2 diabetes mellitus complicated with osteoporosis,and it is safe and effective.

关键词

碳酸钙D3/阿仑膦酸钠/老年2/型糖尿病合并骨质疏松/血清激素/骨密度

Key words

Calcium carbonate D3/Alendronate sodium/Elderly type 2 diabetes mellitus with osteoporosis/Serum hormone/Bone density

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出版年

2024
四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子：0.575
ISSN：1671-3885
参考文献量10
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