Effect of Tirofiban on TIMI blood flow grading and vascular endothelial function in non-ST segment elevation ACS patients
Objective:To investigate the effects of Tirofiban on blood flow classification and vascular endothelial function of thrombolysis therapy(TIMI)in patients with non-ST segment elevation acute coronary syndrome(NSTE-ACS).Methods:62 patients with NSTE-ACS admitted to our hospital from January 2021 to December 2022 were selected as the study objects.Patients were divided into control group and observation group according to alternate grouping method,with 31 cases in each group.The control group was treated with conventional aspirin plus clopidogrel,and the observation group was treated with tirofiban on the basis of control group.Vascular endothelial function[nitric oxide(NO),endothelin(ET)],TIMI blood flow grading and adverse reactions were analyzed and compared between the two groups.Results:After treatment,the level of NO in both groups was higher than before treatment,while the level of ET was lower.The level of NO in the observation group was higher than that in the control group,and the level of ET was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the improvement of TIMI blood grading in observation group was significantly better than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tirofiban has good efficacy in NSTE-ACS patients,which can improve TIMI blood flow classification and vascular endothelial function without increasing adverse reactions.
non-ST segment elevation acute coronary syndromeTirofibanBlood flow classificationVascular endothelial function
万方数据
维普
