Efficacy of compound Xueshuantong capsule combined with ranibizumab in the treatment of diabetic retinopathy and its influence on serum hs-CRP and Ang-2 levels
Objective:To explore the efficacy of compound Xueshuantong capsule combined with ranibizumab in the treatment of diabetic retinopathy(DR)and its influence on levels of serum angiopoietin-2(Ang-2)and serum high-sensitivity C-reactive protein(hs-CRP).Methods:A total of 120 patients(240 eyes)who were diagnosed with diabetic retinopathy in the hospital from June 2019 to December 2021 were selected as the research subjects,and were divided into two groups by the random sampling method,including observation group(n=60,120 eyes)and control group(n=60,120 eyes).The control group was treated with ranibizumab injection while the observation group was additionally given compound Xueshuantong capsule on the basis of the control group.The hs-CRP and Ang-2 levels,central macular thickness(CMT),best-corrected visual acuity(BCVA)and incidence rates of adverse reactions were compared between the two groups of patients before and after treatment.Results:After 6 months of treatment,the hs-CRP level was decreased while the Ang-2 level was increased in the two groups,and the hs-CRP in observation group was lower than that in control group while the Ang-2 was higher than that in control group(P<0.05).After 6 months of treatment,CMT in observation group was thinner than that in control group,and visual acuity was higher than that in control group(P<0.05).The proportion of visual acuity improvement in observation group after treatment was significantly more while the proportion of patients with decreased visual acuity was less compared with that in control group(P<0.05).After treatment,the total incidence rate of adverse reactions was 11.67%in observation group and that in control group was 8.33%(P>0.05).Conclusion:Compound Xueshuantong capsule combined with ranibizumab can effectively reduce the levels of hs-CRP and Ang-2,relieve the retinal edema,enhance the visual acuity,improve the visual function,and greatly promote the quality of life of patients with diabetic retinopathy.
万方数据
维普
