Effects of alfacalcidol tablets and Xuling Jiangu granules on bone mineral density and serum calcium and phosphorus indexes in patients with osteoporosis
Objective:To explore the effects of alfacalcidol tablets combined with Xuling Jiangu granules on bone mineral density and serum calcium and phosphorus in patients with osteoporosis.Methods:A total of 114 patients with osteoporosis admitted to our hospital from March 2022 to June 2022 were randomly divided into the control group(n=57,alfacalcidol 0.5 μg,orally)and the observation group(n=57,alfacalcidol 0.5 μg + a bag of Xuling Jiangu granules,orally).After treatment for 1 m,the clinical efficacy was compared.At the same time,the levels of typeⅠ procollagen N-terminal peptide(PINP),type Ⅰ collagen cross-linked C-terminal peptides(CTX),and serum alkaline phosphatase(ALP)were measured by enzyme-linked immunosorbent assay.Bone mineral density was measured by X-ray bone densitometer,and serum calcium and phosphorus levels were measured by biochemical method.Results:After treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05).The level of bone metabolism in the observation group was significantly improved.The T-score of bone density,serum calcium and phosphorus were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined effect of alfacalcidol tablets and Xuling Jiangu granules is more obvious,safe,and reliable,which is beneficial to regulate bone metabolism,serum calcium,and phosphorus levels,and increase bone mineral density.
OsteoporosisAlfacalcidol tabletsXuling Jiangu GranuleBone mineral densitySerum calcium and phosphorus
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