Relationship between red blood corpuscular volume distribution width/platelet ratio and recurrence and metastasis in patients with advanced gastric cancer after chemotherapy
Objective:To investigate the relationship between the red blood corpuscular volume distribution width(RDW-CV)/platelet ratio and the recurrence and metastasis of patients with advanced gastric cancer after chemotherapy.Methods:The clinical data of 110 patients with advanced gastric cancer who received chemotherapy from the Fourth People's Hospital of Shangqiu from November 2020 to April 2022 were collected for a retrospective study.They were divided into occurrence group and non-occurrence group according to the recurrence and metastasis within 6 months after chemotherapy.A questionnaire was designed to collect the basic data of all patients,such as age,weight,pathological type,location of primary lesion,and previous operation history,by consulting the medical records and follow-up data of patients with advanced gastric cancer.The blood routine,albumin,total protein and creatinine were collected and compared in all patients with advanced gastric cancer at 4 weeks after chemotherapy.The RDW-CV/platelet count(PLT)value was calculated,and the relationship between RDW-CV/PLT ratio and recurrence and metastasis of patients with advanced gastric cancer chemotherapy was analyzed.Results:In 110 patients with advanced gastric cancer,61 cases(55.45%)had recurrence and metastasis within 6 months after chemotherapy.The level of PLT in the occurrence group was significantly higher than that in the non-occurrence group,and the level of RDW-CV/PLT was significantly lower than that in the non-occurrence group(P<0.05).There was no statistic significant difference between the two groups in age,body weight,pathological type and primary lesion location(P>0.05).The results of point binary correlation showed that PLT was positively correlated with recurrence and metastasis in patients with advanced chemotherapy of gastric cancer(r>0,P<0.05),while RDW-CV/PLT was negatively correlated with recurrence and metastasis(r<0,P<0.05).The subject working characteristic(ROC)curve was drawn.The results showed that the area under the curve(AUC)value of RDW-CV/PLT to predict the recurrence and metastasis of patients with advanced chemotherapy of gastric cancer was 0.754,which had a certain predictive effect.Conclusion:RDW-CV/PLT is related to the recurrence and metastasis of patients with advanced chemotherapy of gastric cancer.The smaller the RDW-CV/PLT value,the greater the possibility of recurrence and metastasis.
Gastric cancerRecurrence and metastasisRed blood corpuscular volume distribution widthPlatelet
万方数据
维普
