Expression,regulation,and clinic significance of UBE2A in hepatocellular carcinoma based on public database
Objective:To investigate the expression of ubiquitin-binding enzyme 2A(UBE2A)in hepatocellular carcinoma(HCC)and its relationship with prognosis,regulatory factors,and immune cell infiltration.Methods:The expression of UBE2A in cancer and normal tissues was analyzed by Timer 2.0 database.The GEPIA database was used to analyze the expression and prognosis of UBE2A in HCC.The differentially expressed miRNAs were screened in the hepatocellular carcinoma data set(GSE108724)from the GEO database,and a gene-miRNA regulatory network was constructed using the mirDIP tool.UALCAN Database was used to explore the relationship between UBE2A and clinical features.The relationship between UBE2A and immune cell infiltration was analyzed by the timer database.Results:The expression of UBE2A in HCC was higher than that in normal tissues(P<0.05).The prognosis of patients with high expression of UBE2A was poor(P = 0.045).Hsa-mir-106b-5p,hsa-mir-375,and hsa-mir-93-5p are involved in the regulation of UBE2A in hepatocellular carcinoma.UBE2A gene expression was not correlated with age,gender,and lymph node metastasis(P>0.05),but correlated with tumor stage(P<0.05).UBE2A was positively correlated with the infiltration levels of B cells,CD8+ T cells,CD4+ T cells,macrophages,neutrophils,and dendritic cells.Conclusion:UBE2A is expected to be a new diagnostic marker and a potential molecular target for the therapy of hepatocellular carcinoma.
NETL
NSTL
万方数据
维普
