天麦消渴片结合西格列汀及二甲双胍治疗新发肥胖型2型糖尿病临床效果观察
Clinical effect of Tianmai Xiaoke Tablet combined with Sitagliptin and metformin in the treatment of newly diagnosed obese type 2 diabetes
徐璐璐 1陈小平 1常红叶 1陈贝贝 1李晓玉1
作者信息
- 1. 河南大学第一附属医院内分泌科,河南 开封 475000
- 折叠
摘要
目的:观察新发肥胖型 2型糖尿病患者应用天麦消渴片结合西格列汀及二甲双胍治疗的临床效果.方法:选取 2020 年 6 月至 2023 年 6 月期间本院收治的 98 例新发肥胖型 2 型糖尿病患者作为研究对象.采用随机数字表法将患者分为对照组(n=48)和试验组(n=50).对照组采取西格列汀及二甲双胍治疗,试验组在对照组基础上增加天麦消渴片进行治疗.分析比较两组的疗效、血糖相关指标及肥胖相关指标以及不良反应.结果:试验组治疗后的总有效率高于对照组(P＜0.05).治疗前,两组的空腹血糖(Fasting blood glucose,FPG)、餐后 2 h血糖(2 hour postprandial blood glucose,2h PG)与糖化血红蛋白(Glycosylated hemoglobin,Hb A1c)等血糖指标、体质量与体质量指数(Body mass index,BMI)、腰围(Waist circumference,WC)及体脂率(Body fat rate,BF)等肥胖相关指标均无明显差异(P＞0.05).治疗后,两组的FPG、2 h PG、Hb A1c、体质量、BMI、WC、BF等指标均明显下降,并且试验组治疗后的FPG、2 h PG、Hb A1c、体质量、BMI、WC、BF等指标均明显低于对照组(P＜0.05).试验组(0.00%)与对照组(4.17%)的不良反应率无明显差异(P＞0.05).结论:新发肥胖型 2 型糖尿病患者应用天麦消渴片结合西格列汀及二甲双胍治疗,能提高治疗效果,降低血糖和肥胖症状,且不良反应较少.
Abstract
Objective:Objective To observe the clinical effect of Tianmai Xiaoke tablet combined with sitagliptin and metformin in the treatment of newly obese patients with type 2 diabetes.Methods:98 newly diagnosed obese patients with type 2 diabetes admitted to our hospital from June 2020 to June 2023 were selected as the study objects.Patients were divided into control group(n=48)and experimental group(n=50)by random number table method.The control group was treated with sitagliptin and metformin,and the experimental group was treated with Tianmai Xiaoke tablet on the basis of control group.The efficacy,blood glucose and obesity related indexes and adverse reactions of the two groups were analyzed and compared.Results:The total effective rate of experimental group was higher than that of control group(P<0.05).Before treatment,Fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG)and Glycosylated hemoglobin(Glycosylated hemoglobin)were measured in both groups.There were no significant differences in blood glucose indexes(Hb A1c),Body mass and Body mass index(BMI),Waist circumference(WC),Body fat rate(BF)and other obesity-related indexes(P>0.05).After treatment,FPG,2 h PG,Hb A1c,body mass,BMI,WC,BF and other indexes of both groups were significantly decreased,and FPG,2 h PG,Hb A1c,body mass,BMI,WC,BF and other indexes of test group were significantly lower than those of control group after treatment(P<0.05).There was no significant difference in the adverse reaction rate between the experimental group(0.00%)and the control group(4.17%)(P>0.05).Conclusion:Tianmai Xiaoke tablet combined with sitagliptin and metformin in the treatment of newly obese patients with type 2 diabetes can improve the therapeutic effect,reduce blood sugar and obesity symptoms,and have fewer adverse reactions.
关键词
新发肥胖型2型糖尿病/二甲双胍/西格列汀/天麦消渴片Key words
Newly obese type 2 diabetes mellitus/Metformin/Sitagliptin/Tianmai Xiaoke tablet引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据