Correlation of the use of antibiotics with the resistance of common bacteria in our hospital from 2018 to 2021
Objective:To explore the use of antibiotics in the First People's Hospital of Nanyang City and their correlation with common bacterial resistance.Methods:Positive samples from clinical patients in Nanyang First People's Hospital from Jan.2018 to Dec.2021 were collected,and the pathogenic bacteria isolated from clinical samples,the consumption of common antibiotics in our hospital,and the correlation of the resistance rate(%)of common Gram negative bacteria with frequency of defined daily doses(DDDs)of antibiotics were analyzed.Results:From 2018 to 2021,the antibiotics with high DDDs in our hospital were mezlocillin,ceftazidime,piperacillin tazobactam,and the pathogens with high detection rate were Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,etc.The resistance rate of Escherichia coli was correlated with the DDDs of piperacillin tazobactam and cefuroxime sodium(r=-0.107 and 0.432,respectively);the drug resistance rate of Klebsiella pneumoniae was positively correlated with the DDDs of piperacillin tazobactam,levofloxacin sodium chloride and cefuroxime sodium(r=0.410,0.720,and 0.420,respectively);Pseudomonas aeruginosa was positively correlated with the DDDs of piperacillin tazobactam and cefoperazone sulbactam sodium(r=0.716,0.933,respectively);the drug resistance rate of Staphylococcus aureus was positively correlated with the DDDs of levofloxacin(r=0.661);the resistance rate of Streptococcus pneumoniae was positively correlated with the DDDs of levofloxacin and cefuroxime sodium(r=0.416 and 0.482,respectively).Conclusion:The DDDs of antibiotics are correlated with the resistance of common bacteria.Our hospital should strictly control the use of antibiotics,select appropriate antibiotics based on infectious diseases and drug sensitivity test results,and strengthen drug resistance monitoring of common pathogens.
NETL
NSTL
万方数据
维普
