Application effects of different blue light irradiation frequencies on neonatal hyperbilirubinemia
Objective:To compare the efficacy of different blue light irradiation frequencies in the treatment of neonatal hyperbilirubinemia.Methods:126 children with hyperbilirubinemia who were treated in the hospital between December 2019 and February 2022 were enrolled as the research subjects,and they were divided into the control group(n=63)and the observation group(n=63)according to the random odd-even number method.Both groups of children received conventional drug treatment,and the control group was given long-term blue light irradiation based on conventional drug therapy,and the observation group received intermittent blue light irradiation based on conventional drug therapy.The jaundice subsidence time,hospital stay,meconium emptying time and stool frequency were compared between the two groups,and the levels of serum bilirubins[indirect bilirubin(IBiL),total bilirubin(TBiL)]and serum biochemical-related indicators[Cystatin C(CysC),α-glutathione-S transferase(α-GST),glutamate dehydrogenase(GLDH)]of the two groups were compared before treatment and on the 5th d of treatment,and the adverse reactions of the two groups were compared.Results:The jaundice subsidence time,hospital stay,meconium emptying time and stool frequency in the observation group were shorter or less than those in the control group(P<0.05).On the 5th d of light treatment,the levels of serum IBiL and TBiL in the two groups were significantly decreased(P<0.05),and the levels were significantly lower in the observation group than those in the control group(P<0.05).Serum levels of CysC,α-GST and GLDH in the two groups were significantly reduced on the 5th d of light treatment(P<0.05),and the above indicators in the observation group were significantly lower than those in the control group(P<0.05).During treatment,the total adverse reaction rate in the observation group was 11.11%,which was significantly lower than 26.98%in the control group(P<0.05).Conclusion:Intermittent blue light irradiation in the treatment of neonatal hyperbilirubinemia can significantly shorten the jaundice subsidence time,promote the meconium emptying,and reduce the bilirubin,and it has few adverse reactions and is worthy of clinical application.
Intermittent blue light irradiationLong-term blue light irradiationNeonatal hyperbilirubinemiaBilirubin
NETL
NSTL
万方数据
维普
