Effect of mometasone combined with montelukast sodium in the treatment of allergic rhinitis and its effect on the regulation of serum Th1/Th2 cytokine expression
Objective:To study the effect of mometasone combined with montelukast sodium in the treatment of allergic rhinitis(AR)and the effect on the regulation of serum Th1/Th2 cytokine expression.Methods:A total of 82 AR patients admitted to our hospital from March 2020 to March 2022 were selected as the research object.The patients were divided into group A and group B randomly,with 41 cases in each group.Group A was treated with Mometasone furoate,group B was treated with Mometasone furoate combined with Montelukast sodium.Clinical efficacy,clinical symptom score,serum Th1/Th2 cytokines[interleukin-2(IL-2),interferon-γ(IFN-γ),interleukin-4(IL-4),interleukin-10(IL-10)]levels,serum chemokine ligand 17(CCL17),chemokine ligand 22(CCL22)levels and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of group B was higher than that of group A(P<0.05).The clinical symptom scores in group B were lower than those in group A after 1 month and 3 months of treatment(P<0.05);After 1 month and 3 months of treatment,the serum levels of IL-2 and IFN-γ in group B were higher than those in group A,while the levels of IL-4 and IL-10 were lower than those in group A(P<0.05).The serum levels of CCL17 and CCL22 in group B were lower than those in group A after 1 month and 3 months of treatment(P<0.05);The total incidence of adverse reactions in the two groups was no significant difference.Conclusion:On the basis of mometasone furoate in the treatment of AR,Montelukast sodium can further improve the curative effect,improve clinical symptoms,regulate serum Th1/Th2 cytokines,and promote the recovery of the disease.
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NSTL
万方数据
维普
