Effects of folic acid combined with alendronate sodium on bone mineral density,bone metabolism indexes,and fibrocyte growth factor levels in postmenopausal patients with osteoporosis
Objective:To investigate the effects of folic acid combined with alendronate sodium on fibrocyte growth factor,bone metabolism,and bone mineral density in postmenopausal patients with osteoporosis.Method:A total of 106 postmenopausal osteoporosis patients admitted to our department from April 2020 to June 2022 were randomly divided into two groups(n=53).The control group received alendronate sodium 10 mg and lipoic acid 0.6 g once·d-1,while the observation group received alendronate sodium 10 mg and folic acid 2 tablets once·d-1.After 6 m of treatment,bone densitometry was used to determine the bone density of the femoral greater trochanter,femoral neck,femoral shaft,and the second and fourth lumbar vertebra(L2-L4),and enzyme-linked immunosorbent assay was used to determine Osteoprotegerin(OPG),receptor activator of NF-KB ligand(RANKL),type Ⅰ C-tenninal cross-linked peptide(CTX-1),and fibroblast growth factor(FGF)levels.Bone glaprotein(BGP)level was detected by electrochemiluminescence immunoassay.Follow-up was performed to observe the adverse reactions in each patient.Results:Compared with before treatment,bone density,OPG,and BGP of the femoral greater trochanter,femoral neck,femoral shaft,and L2-L4 were significantly increased in all treatment groups(P<0.05),especially in the observation group(P<0.05).Compared with before treatment,RANKL,CTX-1,FGF-23,and FGF-21 in the treatment groups were significantly decreased(P<0.05),and the decrease was more significant in the observation group(P<0.05),there was no statistical difference in adverse reactions between the two groups(P>0.05).Conclusion:Oral treatment of alendronate sodium combined with folic acid can effectively regulate FGF levels,and improve bone metabolism and bone mineral density in postmenopausal patients with osteoporosis,with fewer adverse reactions.
Postmenopausal osteoporosisAlendronate sodiumFibroblast growth factorBone metabolismBone density
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NSTL
万方数据
维普
