Effect of rizuzumab on the ocular artery blood hemodynamics,levels of atrial vasoactive substances and inflammatory factors in patients with neovascular glaucoma
Objective:To investigate the effect of rizumab on the the ocular artery blood hemodynamics,levels of vasoactive substances and inflammatory factors in patients with neovascular glaucoma(NVG).Methods:86 cases of NVG patients undergoing vitrectomy admitted to ophthalmology of our hospital from January 2021 to June 2022 were selected as study subjects and randomly divided into two groups(43 patients in each group).The control group was treated with vitrectomy,and the observation group received intravitreal ranizumab based on the control group.The intraocular pressure(IOP)level,ocular artery blood hemodynamics,levels of aqueous vasoactive substances and inflammatory factors,and adverse reactions were observed in two groups.Results:The IOP decreased one week after treatment,1 month after treatment and 3 months after treatment,and the IOP of the observation group was lower than that of the control group(P<0.05).After treatment,the Vascular resistance index(RI)after treatment were all decreased,And RI in the observation group was lower than that in the control group(P<0.05);Peak systolic flow velocity(PSV)and end-diastolic velocity(EDV)in both eye groups were all elevated,And they in the observation group were higher than those in the control group(P<0.05);levels of vascular endothelial growth factor(VEGF),interleukin-6(IL-6)were all lower,Moreover,they in the observation group was lower than those in the control group(P<0.05);There was no significant difference in the incidence of adverse effects between the two groups.Conclusion:Intravitreal injection of ranizumab to treat NVG can reduce IOP,improve ocular artery flow and inhibit the levels of VEGF and IL-6 in aqueous humor,without increasing adverse stress.
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