Effect of miR-155 and miR-126 expression levels in cerebrospinal fluid on prognosis of hypertensive cerebral hemorrhage patients
Objective:To investigate the effect of miR-155(microRNA-155)and miR-126 in cerebrospinal fluid of patients with hypertensive cerebral hemorrhage on prognosis.Methods:129 patients with hypertensive cerebral hemorrhage admitted to our hospital from January 2020 to December 2022 were collected as research objects.According to the National Institutes of Health Stroke Scale(NIHSS)score,the patients were divided into three groups:severe stroke,moderate stroke and mild stroke.Baseline data of the three groups were analyzed and compared.The expression levels of miRNA-155 and miRNA-126 were analyzed on the first day after admission.Correlation of miRNA-155 and miRNA-126 with hematoma volume,neuron-specific enolase(NSE),Neurofilament light chain(NfL),and NIHSS score.The relationship between miRNA-155,miRNA-126 and NSE,NfL,APACHE II(Acute Physiology and Chronic Health Evaluation II)scores and ModifiedRankin Scale(mRS),NIHSS score correlation were analyzed on the 14th day after admission.The receiver operating characteristic curve(ROC)was drawn to analyze the value of miRNA-155 and miRNA-126 alone and in combination in detecting the prognosis of patients with cerebral hemorrhage.Results:The amount of hematoma,the proportion of diabetes mellitus,the expression levels of miRNA-155,miRNA-126,NSE and NfL in the severe stroke group were significantly different from those in the other two groups(P<0.05).The expression of miRNA-155 was inversely correlated with the amount of hematoma,NSE and NfL,while miRNA-126 was inversely correlated(P<0.05).miRNA-155 was negatively correlated with NSE,NfL and APACHE II scores,while miRNA-126 was negatively correlated with NSE,NFL and Apache II scores(P<0.05).The sensitivity and specificity of miRNA-155 and miRNA-126 for prognosis were 95.6%and 93.2%,respectively,at 14 days after admission.Conclusion:The levels of miRNA-155 and miRNA-126 in CSF 14 days after admission reflect the severity of hypertensive intracerebral hemorrhage to a certain extent,and have certain clinical significance for the prognosis of patients.
NETL
NSTL
万方数据
维普
