首页|甲氨蝶呤辅助高强度聚焦超声预处理对宫腔镜微创清宫术在瘢痕子宫妊娠患者中的效果观察

甲氨蝶呤辅助高强度聚焦超声预处理对宫腔镜微创清宫术在瘢痕子宫妊娠患者中的效果观察

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目的:探析瘢痕子宫妊娠(caesarean scar pregnancy,CSP)患者治疗中,甲氨蝶呤(methotrexate,MTX)辅助高强度聚焦超声(High Intensity Focused Ultrasound,HIFU)在宫腔镜微创清宫术中的应用效果.方法:选 2021年 2 月至 2022 年 4 月本院 90 例CSP患者,均采用宫腔镜微创清宫术治疗,随机分为两组,各 45 例,对照组用HIFU预处理,观察组采用HIFU+MTX预处理,术后 1 m评估患者的恢复情况、妊娠不良结局与并发症,术后半年采用生活质量(Quality of Life Rating,SF-36)评分评估患者的生活质量.结果:两组出血量相比,观察组较少;观察组恢复时间、住院时间均短于对照组;术后半年观察组 SF-36 评分高于对照组(P<0.05);两组妊娠结局、足月分娩、早产率无显著差异(P>0.05),观察组妊娠并发症的发生率低于对照组(P<0.05).结论:MTX辅助HIFU用于CSP患者宫腔镜微创清宫术中,能够有效减少手术出血,缩短治疗时间,提高患者术后半年的生活质量,不影响患者的妊娠结局,有效降低妊娠并发症.
Observation on the Effect of High Intensity Focused Ultrasound Preconditioning Assisted with Methotrexate on Minimally Invasive Hysteroscopic Hysteroscopic Clearance in Patients with Scarred Uterine Pregnancy
Objective:To explore the application effect of methotrexate(MTX)assisted high intensity focused ultrasound(HIFU)in minimally invasive hysteroscopic curettage in the treatment of scar uterine pregnancy(CSP)patients.Methods:90 CSP patients in our hospital from February 2021 to April 2022 were selected and treated with minimally invasive hysteroscopic curettage.They were randomly divided into two groups,with 45 cases in each group.The control group received HIFU pretreatment,while the observation group received HIFU+MTX pretreatment.The patient's recovery,adverse pregnancy outcomes,and complications were evaluated one month after surgery.The quality of life(SF-36)score was used to evaluate the patient's quality of life six months after surgery.Result:Compared with the two groups,the observation group had less bleeding;The recovery time and hospitalization time of the observation group were shorter than those of the control group;The observation group scored higher than the control group half a year after surgery(P<0.05);There was no difference in pregnancy outcomes,full-term delivery,and preterm birth rates between the two groups(P>0.05).The incidence of pregnancy complications in the observation group was lower than that in the control group(P<0.05).Conclusion:MTX assisted HIFU can effectively reduce surgical bleeding,shorten treatment time,improve patients'quality of life six months after surgery,without affecting pregnancy outcomes,and effectively reduce pregnancy complications in CSP patients undergoing minimally invasive hysteroscopic curettage.

Minimally invasive hysteroscopic curettageHigh intensity focused ultrasoundMethotrexateScared uterine pregnancy

郭学玲、郑玉霞、崔风云、王晓晓

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汝州市第一人民医院妇产科,河南 汝州 467500

宫腔镜微创清宫术 高强度聚焦超声 甲氨蝶呤 瘢痕子宫妊娠

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子:0.575
ISSN:1671-3885
年,卷(期):2024.46(2)
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