Effects of canagliflozin combined with dulaglutide on blood glucose level and renal function in elderly patients with diabetic nephropathy
Objective:To study the effects of the treatment of canagliflozin combined with Dulaglutide on blood glucose and renal function in elderly patients with diabetic nephropathy.Methods:Eighty-two patients with diabetic nephropathy admitted to our hospital from January 2021 to August 2022 were randomly divided into the control and the observation groups(n=41)and treated with dulagliptin(subcutaneous injection,1.5 mg·time-1,1 time·w-1)and canagliflozin(oral,100 mg·time-1,Qd)combined with dulagliptin,respectively.The clinical efficacy of the two groups was compared after 3 m of treatment,fasting blood glucose(FBG)and postprandial blood glucose 2 hours(2hPBG)levels were measured using glucose oxidase assay,24-hour urine protein was detected using turbidimetry,and serum creatinine(Scr),and urea nitrogen(BUN)levels were measured using a fully automated biochemical analyzer,double antibody sandwich enzyme-linked immunosorbent assay was used to detect serum levels of recombinant transforming growth factor beta 1(TGF-β1),Pentraxin 3(Ptx3),and α-klotho protein.The level of tumor necrosis factor-α(TNF-α)was measured by radioimmunoassay and the incidence of adverse reactions was recorded.Results:After 3 m of treatment,the total clinical effective rate of the observation group was higher than that of the control group.Also,blood glucose levels,renal function indicators,and the levels of serum TGF-β1,TNF-α,and Ptx3 were lower than that of the control group,α-klotho protein levels were higher than those in the control group(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:The treatment of elderly patients with diabetic nephropathy with the combination of canagliflozin and dulaglutide is effective,can effectively control blood sugar,improve renal function and promote recovery,and is safe and feasible.
CanagliflozinDulaglutideDiabetic nephropathyBlood glucoseRenal function
NETL
NSTL
万方数据
维普
