Changes and clinical significance of serum ChE,PA,HMGB1 levels in patients with chronic obstructive pulmonary disease and respiratory failure
Objective:To investigate the serum levels of cholinesterase(ChE),prealbumin(PA)and high mobility group protein B1(HMGB1)in patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure,and analyze their predictive value for prognosis.Methods:86 COPD patients with respiratory failure admitted to our hospital from January 2021 to December 2022 were selected as the study group,while 82 simple COPD patients admitted to our hospital during the same period were selected as the control group,and 56 healthy volunteers who underwent physical examinations in our hospital during the same period were selected as the health group.Compare the levels of serum ChE,PA,and HMGB1 in different groups.The patients in the study group received routine treatment and were divided into survivors and deceased patients based on their prognosis within 28 days of hospitalization.The patients in the study group received routine treatment and were divided into survivors and deceased patients based on their prognosis within 28 days of hospitalization.Compare and analyze the serum levels of various indicators among survivors and deceased patients before treatment,7 days after treatment,and 14 days after treatment,and to analyze their correlation with acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)and their predictive value for prognosis.Results:The levels of ChE and PA in the study group were lower than those in control group and healthy group,and the levels of HMGB1 were higher than those in control group and healthy group(P<0.05).After 7 days and 14 days of treatment,the serum ChE and PA levels of the deceased were lower than those of the survivors,while HMGB1 levels were higher than those of the survivors(P<0.05).The AUC of ChE,PA and HMGB1 in predicting prognosis was greater than that of single index after 7 and 14 days of treatment,and the AUC of combined serum indexes in predicting prognosis after 14 days of treatment was greater than that of combined serum indexes after 7 days of treatment(P<0.05).Conclusion:There are significant differences in serum ChE,PA and HMGB1 levels in patients with COPD combined with respiratory failure with different disease severity and prognosis,and they are closely related to APACHEⅡ score.Combined detection of CHE,PA and HMGB1 levels has certain predictive value for prognosis.
Chronic obstructive pulmonary diseaseRespiratory failureCholinesteraseProalbuminHigh mobility group protein B1
NETL
NSTL
万方数据
维普
