Effects of Smeglutide combined with metformin on blood glucose and islet function in obese type 2 diabetes patients
Objective:To investigate the effects of Smeglutide combined with metformin on obese patients with type 2 Diabetes mellitus(T2DM).Methods:One hundred and twenty-eight obese T2DM patients admitted to our hospital from February 2022 to February 2023 were randomly divided into the study group(Smeglutide combined with metformin treatment)and the control group(metformin treatment),64 cases each.After 2-month of treatment,the efficacy,blood glucose biochemical indices,islet function indices,body mass index(BMI),body composition indices,and vascular endothelial function indices of the two groups were compared.Fasting plasma glucose(FPG)and 2 Hours postprandial blood glucose(2hPG)were measured by glucose oxidase.HemoglobinA1c(HbA1c)level was detected by chromatography,fasting insulin fins(FINS)level was measured by chemiluminescence method,and body composition indexes(body fat percentage and visceral fat content)were detected by dual-energy X-ray method.Endothelin-1(ET-1)levels were determined by enzyme-linked immunoassay and Nitrogen monoxide(NO)levels by nitric reductase.The endothelin-1(ET-1)levels were detected by nitric oxide(NO).Results:The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the improvement of blood glucose biochemistry,islet function,BMI and body composition indexes,NO,and ET-1 levels were better than those of the control group(P<0.05).Conclusions:Smeglutide combined with metformin is effective in the treatment of obese T2DM patients,which can restore normal blood glucose,reduce insulin resistance,improve body mass index,and promote the secretion of pancreatic β cells.
NETL
NSTL
万方数据
维普
