Clinical effects of Camrelizumab in combination with concurrent chemoradiation in the treatment of locally advanced esophageal cancer
Objective:To study the effect of Camrelizumab combined with concurrent chemoradiotherapy in patients with locally advanced esophageal cancer.Methods:Sixty patients with locally advanced esophageal cancer admitted to our hospital from January 2020 to February 2022 were randomly divided into two groups:the control group(n=30,received fluorouracil + cisplatin concurrent chemoradiotherapy)and the combined group(n=30 received Camrelizumab based on the control group),21 days was a cycle.The incidence of toxic and side effects in the two groups and the efficacy of the two groups after 3 cycles of treatment were recorded and analyzed,Karnofsky performance scale(KPS)score was used to evaluate the quality of life before and after 3 cycles of treatment.Cytokeratin 19 fragment antigen 21-1(CYFRA21-1)was determined by chemiluminescence.Serum stathmin1(STMN1),squamous cell carcinoma-associated antigen(SCC),carbohydrate antigen 125(CA125),matrix metalloproteinase-9(MMP-9),carcinogenic antigen(CEA),vascular endothelial growth factor(VEGF),and thrombin sensitive protein-1(TSP-1)were determined by enzyme-linked immunosorbent assay.Results:The total clinical effective rate of the combination group was significantly higher than that of the control group(P<0.05).After treatment,the KPS score of the combination group was higher than that of the control group(P<0.05).After treatment,the serum SCC,CA125,CYFRA21-1,CEA,STMN1,MMP-9,and VEGF in the combination group were lower than those in the control group,and TSP-1 was higher than those in the control group(P<0.05).There was no significant difference in the incidence of toxic and side effects between the two groups(P>0.05).Conclusion:The application of Camrelizumab combined with concurrent chemoradiotherapy in patients with locally advanced esophageal cancer can regulate the expression levels of tumor markers and vascular endothelial-related factors,improve the therapeutic effect and improve patients'quality of life.
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