Effect analysis of amantadine combined with Donepezil in the treatment of Parkinson's disease
Objective:To investigate the efficacy of amantadine combined with Donepezil in the treatment of Parkinson's disease.Methods:76 patients with Parkinson's disease treated in our hospital from September 2020 to October 2022 were prospectively selected as research objects.The patients were divided into control group and observation group with 38 cases in each group by random number table method.The control group was treated with amantadine.Observation group was treated with amantadine combined with Donepezil.Both groups were treated continuously for 6 months.The clinical efficacy,total scores of the Unified Parkinson's Disease Rating Scale(UPDRS)before and after 6 months of treatment and adverse reactions during treatment were analyzed and compared between the two groups.Results:After 6 months of treatment,the total effective rate of observation group was higher than that of control group(P<0.05).Before treatment,there was no significant difference in UPDRS scores between the two groups(P>0.05).After 6 months of treatment,the UPDRS scores and total scores of both groups were significantly lower than those before treatment,and the UPDRS scores and total scores of the observation group were significantly lower than those of the control group(P<0.05).During treatment,there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Amantadine combined with Donepezil can enhance the clinical efficacy of patients with Parkinson's disease and reduce the incidence of Parkinson's disease without increasing the incidence of adverse reactions.It is safe and worthy of clinical application.
NETL
NSTL
万方数据
维普
