硝苯地平联合阿托伐他汀对冠心病伴高血压患者血压控制水平及血管内皮功能的影响
Blood pressure control level of nifedipine combined with atorvastatin in patients with coronary heart disease and hypertension and the effect of vascular endothelial function
余波 1席罡 1华永平1
作者信息
- 1. 景德镇市第三人民医院,江西 景德镇 333000
- 折叠
摘要
目的:分析硝苯地平联合阿托伐他汀对冠心病伴高血压患者血压控制水平及血管内皮功能的影响.方法:选择本院 2021 年 7 月至 2023 年 3 月收治的冠心病伴高血压患者(n=80),使用随机数字表法将纳入患者分为对照组(n=40)和观察组(n=40).对照组给予硝苯地平治疗,观察组给予硝苯地平联合阿托伐他汀治疗,两组均持续治疗 6 w.对比两组患者血压控制水平、血脂[低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、总胆固醇(TC)]、血管内皮功能[血浆内皮素-1(ET-1)、一氧化氮(NO)]、疗效、不良反应.结果:治疗6 w后,观察组的舒张压和收缩压以及LDL、HDL、TC水平均低于对照组(P＜0.05).观察组患者ET-1 水平低于对照组(P＜0.05),NO水平高于对照组(P＜0.05).观察组治疗总有效率高于对照组(P＜0.05).两组患者不良反应发生率差异无统计学意义(P＞0.05).结论:硝苯地平联合阿托伐他汀能够有效控制冠心病伴高血压患者的血压水平和血脂水平,改善血管内皮功能,疗效更好.
Abstract
Objective:To analyze the effects of nifedipine combined with atorvastatin on blood pressure control and vascular endothelial function in patients with coronary heart disease and hypertension.Methods:Patients with CHD and hypertension admitted to our hospital from July 2021 to March 2023(n=80)were selected and divided into control group(n=40)and observation group(n=40)using random number table method.The control group was treated with nifedipine,and the observation group was treated with nifedipine combined with atorvastatin.Both groups were treated for 6 weeks.Blood pressure control level,blood lipids[low density lipoprotein(LDL),high density lipoprotein(HDL),total cholesterol(TC)],vascular endothelial function[plasma endothelin-1(ET-1),nitric oxide(NO)],efficacy and adverse reactions were compared between the two groups.Results:After 6 weeks of treatment,the diastolic blood pressure,systolic blood pressure,LDL,HDL and TC levels in observation group were lower than those in control group(P<0.05).The level of ET-1 in observation group was lower than that in control group(P<0.05),and the level of NO was higher than that in control group(P<0.05).The total effective rate of observation group was higher than that of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Nifedipine combined with atorvastatin can effectively control blood pressure and lipid levels in patients with coronary heart disease and hypertension,improve vascular endothelial function and have better curative effect.
关键词
冠心病/高血压/硝苯地平/阿托伐他汀/血压/血管内皮功能Key words
Coronary heart disease/High blood pressure/Nifedipine/Atorvastatin/Blood Pressure/Vascular endothelial function引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据