Blood pressure control level of nifedipine combined with atorvastatin in patients with coronary heart disease and hypertension and the effect of vascular endothelial function
Objective:To analyze the effects of nifedipine combined with atorvastatin on blood pressure control and vascular endothelial function in patients with coronary heart disease and hypertension.Methods:Patients with CHD and hypertension admitted to our hospital from July 2021 to March 2023(n=80)were selected and divided into control group(n=40)and observation group(n=40)using random number table method.The control group was treated with nifedipine,and the observation group was treated with nifedipine combined with atorvastatin.Both groups were treated for 6 weeks.Blood pressure control level,blood lipids[low density lipoprotein(LDL),high density lipoprotein(HDL),total cholesterol(TC)],vascular endothelial function[plasma endothelin-1(ET-1),nitric oxide(NO)],efficacy and adverse reactions were compared between the two groups.Results:After 6 weeks of treatment,the diastolic blood pressure,systolic blood pressure,LDL,HDL and TC levels in observation group were lower than those in control group(P<0.05).The level of ET-1 in observation group was lower than that in control group(P<0.05),and the level of NO was higher than that in control group(P<0.05).The total effective rate of observation group was higher than that of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Nifedipine combined with atorvastatin can effectively control blood pressure and lipid levels in patients with coronary heart disease and hypertension,improve vascular endothelial function and have better curative effect.
Coronary heart diseaseHigh blood pressureNifedipineAtorvastatinBlood PressureVascular endothelial function
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NSTL
万方数据
维普
