Effects of Ligustrazine combined with low molecular weight heparin calcium on levels of sFlt-1,VEGF,PLGF,ET-1 and pregnancy outcome in pregnant preeclampsia patients
Objective:To investigate the influence of Ligustrazine combined with Low molecular weight heparin calcium treatment on serum fms-like tyrosine kin-1(sFlt-1),vascular endothelial growth factor(VEGF),placental growth factor(PLGF),endothelin-1(ET-1)level and pregnancy outcome in pregnant women with preeclampsia.Methods:A prospective study was conducted in 102 pregnant women with preeclampsia admitted to our hospital from January 2022 to January 2023.They were divided into reference group(51 cases)and combination group(51 cases)randomly.The reference group was treated with low molecular weight heparin calcium,and the combination group was treated with low molecular weight heparin calcium and Ligustrazine.Diastolic blood pressure,systolic blood pressure,mean arterial pressure,24 h urinary protein,D-dimer(D-D),fibrinogen(FIB),thrombin time(TT),prothrombin time(PT),serum sFlt-1,VEGF,PLGF,ET-1 levels,gestational age of termination,neonatal body mass,Apgar score and neonatal asphyxia ratio were compared between the two groups before and after treatment.Results:After treatment,the levels of diastolic blood pressure,systolic blood pressure,mean arterial pressure,24 h urinary protein quantity,plasma D-D,FIB,serum sFlt-1 and ET-1 in combination group were lower than those before treatment and in reference group;while the levels of plasma TT,PT,serum VEGF and PLGF were higher than those before treatment and in reference group,the gestational circumference of the combination group was higher than that of the control group,and the body mass and Apgar score of the newborn were higher than those of the control group(P<0.05).However,there was no significant difference in the proportion of neonatal asphyxia between the two groups.Conclusion:The treatment of Ligustrazine combined with low molecular weight heparin calcium can reduce the blood pressure level of pregnant women with preeclampsia,reduce urinary protein level,improve coagulation function,and alleviate endothelial injury,so as to prolong gestational age,improve newborn body weight and Apgar score,which can provide reference for clinical treatment of preeclampsia during pregnancy.
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万方数据
维普
