Effect of bortezomib in the treatment of elderly multiple myeloma and its influence on bone metabolism and levels of NAG and β2-MG
Objective:To explore the effect of bortezomib(BTZ)in the treatment of elderly multiple myeloma(MM)and the influence on bone metabolism and levels of urinary lysosomal enzyme N-acetyl-β-D-glucosaminidase(NAG)and β2-microglobulin(β2-MG).Methods:Seventy-eight elderly patients with MM who were treated in department of hematology of the hospital from March 2020 to December 2021 were selected as the study subjects and were divided into control group and observation group according to the random number table method,with 39 cases in each group.The control group received thalidomide(THD)treatment,and the observation group was given BTZ treatment.The therapeutic efficacy,bone marrow function,bone metabolism indicators,renal function and safety were compared between the two groups.Results:The total effective rate of treatment in observation group was significantly higher than that in control group(P<0.05).The hemoglobin level in observation group after treatment was significantly higher than that in control group(P<0.05)while the levels of serum M protein,bone marrow plasma cell,nuclear factor KB receptor activation factor ligand,human tartrate-resistant acid phosphatase,NAG,cystatin and β2-MG were significantly lower than those in control group(P<0.05).The total incidence rate of adverse reactions was significantly lower in observation group than that in control group(P<0.05).Conclusion:BTZ has a good effect in the treatment of elderly MM,and it can effectively improve the bone marrow function and reduce the bone metabolism level,and it has small effect on renal function and has relatively high safety in clinical application.
NETL
NSTL
万方数据
维普
