Effect of Jianpi Dizhuo Decoction on moderate and severe OSAHS and its effect on oxidative stress level
Objective:To investigate the effect of Jianpi Dizhuo Decoction on the treatment of moderate and severe Obstructive sleep apnea hypopnea syndrome(OSAHS),and to investigate the effect of the decoction on oxidative stress.Methods:A total of 103 patients with moderate to severe OSAHS admitted to our department from July 2020 to 2022 May were selected,and divided into two groups by random number table method.51 patients in the control group were given non-invasive positive pressure ventilation combined with medical nutrition treatment,and 52 patients in the observation group were given combined treatment Jianpi Dizhuo decoction on the basis of control group.,Symptom improvement,oxidative stress index and occurrence of adverse reactions and the clinical effects of the two groups were compared..Results:After treatment,the Apnea hypoventilation index(AHI),longest apnea time and average apnea time in the observation group were all lower than those in the control group,and the Lowest saturation oxygen(LSpO2)was higher than that of control group(P<0.05).The TCM syndrome scores and Epworth Sleepiness Scale(ESS)in observation group were lower than those in control group,and Malondialdehyde(MDA)was lower than in control group.The total effective rate of Superoxide dismutase(SOD)was higher than that of control group(P<0.05).There was no significant difference in ADR between 2 groups(P>0.05).Conclusion:Jianpi Dizhuo Decoction can significantly improve blood oxygen saturation,shorten the duration of apnea,reduce daytime sleepiness and improve oxidative stress state in patients with moderate and severe OSAHS,which is effective and worthy of clinical recommendation.
Jianpi Dizhuo DecoctionObstructive sleep apnea hypopnea syndromeOxidative stressApnea hypopnea index
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NSTL
万方数据
维普
