Expression of serum inflammatory mediators and TGF-β1/Smads in patients with different severity of neurogenic bladder complicated with sepsis and its clinical significance
Objective:To study the expression of serum inflammatory mediators and TGF-β1/Smads in patients with neurogenic bladder complicated with sepsis and its clinical significance.Methods:120 patients with neurogenic bladder complicated with acute infection treated in our hospital from January 2016 to June 2019 were selected as the observation group.According to the scores of systemic inflammatory response syndrome(SIRS)and sequential organ failure(SOFA),the patients were divided into simple infection group(55 cases),sepsis group(39 cases)and severe sepsis group(26 cases).In addition,120 patients with no neurogenic bladder infection were selected as the control group.The levels of TGF-β1,SMAD4,SMAD7,TNF-α,IL-1β and PGE2 in patients with different severity were compared between the observation group and the control group.Results:TGF-β1(t=6.379,P<0.001)and SMAD7(t=13.585,P<0.001)in observation group were significantly higher than those in control group,and SMAD4(t=7.507,P<0.001)were significantly lower than those in control group.The levels of TGF-β1(F=9.263,P<0.001),SMAD4(F=15.016,P<0.001),SMAD7(F=9.657,P<0.001)in patients with the different severity were statistically significant.TGF-β1 and SMAD7 were simple infection group,sepsis group and severe sepsis group from low to high,and SMAD4 was simple infection group,sepsis group and severe sepsis group from high to low.The levels of TNF-α(t=59.196,P<0.001),IL-1β(t=39.525,P<0.001)and PGE2(t=69.264,P<0.001)in observation group were significantly higher than those in control group.The levels of TNF-α(F=47.805,P<0.001),IL-1β(F=135.449,P<0.001)and PGE2(F=34.287,P<0.001)in patients with different severity were statistically significant.TNF-α,IL-1β and PGE2 were divided into simple infection group,sepsis group and severe sepsis group from low to high.Conclusion:With the aggravation of neurogenic bladder complicated with sepsis,TGF-β1 and SMAD7 showed a significant upward trend,and SMAD7 significantly decreased,which can be used as an important basis for clinical diagnosis.
NETL
NSTL
万方数据
维普
