Correlation analysis of HGF,IL-10 levels and adverse pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy
Objective:To analyze the relationship between serum hepatocyte growth factor(HGF),interleukin-10(IL-10)and adverse pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy(ICP).Methods:115 ICP patients treated in our hospital from June 2019 to June 2022 were selected.Serum HGF and IL-10 levels were detected,followed up until delivery,and adverse pregnancy outcomes such as fetal distress and neonatal asphyxia were observed and recorded.According to different pregnancy outcomes,the patients were divided into adverse pregnancy outcome group and normal pregnancy outcome group.Baseline data and laboratory indicators were collected and compared between the two groups.To analyze the correlation between serum HGF,IL-10 and adverse pregnancy outcomes in ICP patients.Results:Among the 115 ICP patients,28 cases had adverse pregnancy outcomes,accounting for 24.35%,including 8 cases of fetal distress,7 cases of neonatal asphyxia,4 cases of postpartum hemorrhage,and 9 cases of premature delivery.Serum HGF and IL-10 levels in the adverse pregnancy group were significantly lower than those in the normal pregnancy group(P<0.05).There was no significant difference in maternal type,age and pre-pregnancy body mass index between the two groups(P>0.05).The results showed that serum HGF and IL-10 levels were correlated with adverse pregnancy outcomes in ICP patients(P<0.05).Logistic regression analysis showed that serum HGF and IL-10 were associated with adverse pregnancy outcomes in ICP patients(P<0.05).Conclusion:Serum HGF and IL-10 levels are correlated with adverse pregnancy outcomes in ICP patients.
intrahepatic cholestasis of pregnancyAdverse pregnancyHepatocyte growth factorInterleukin-10
NETL
NSTL
万方数据
维普
