血清CRP、PCT水平与结直肠癌患者术后吻合口瘘发生的相关性
Correlation between serum CRP and PCT levels and postoperative anastomotic fistula in patients with colorectal cancer
韩建波1
作者信息
- 1. 光山县人民医院普通外科,河南 信阳 465450
- 折叠
摘要
目的:分析血清C反应蛋白(C-reactive protein,CRP)、降钙素原(Procalcitonin,PCT)水平与结直肠癌术后吻合口瘘发生的关系.方法:收集 2021 年 3 月至 2022年 11 月在收治的 60 例结直肠癌患者的临床资料,统计吻合口瘘的发生情况并根据是否发生吻合口瘘,将发生吻合口瘘的纳入发生组,未发生纳入未发生组.分析对比两组血清CRP、PCT水平,分析血清CRP、PCT水平与结直肠癌患者术后吻合口瘘发生关系.结果:发生组血清 PCT、CRP 水平显著高于未发生组(P＜0.05).经多元 Logistic 回归分析,血清 PCT(β=0.859,OR=2.360,95%CI为 1.103-5.050)、CRP(β=5.781,OR=324.079,95%CI为 2.573-40811.649)水平与结直肠癌患者术后吻合口瘘发生有关(P＜0.05).绘制受试者工作曲线(ROC)显示,血清PCT、CRP水平单独及联合检测预测结直肠癌患者:术后吻合口瘘发生的曲线下面积(AUC)＞0.7.结论:血清CRP、PCT水平高与结直肠癌患者术后吻合口瘘的发生有关.
Abstract
Objective:To analyze the relationship between the levels of C-reactive protein(CRP)and Procalcitonin(PCT)in serum and the incidence of anastomotic fistula after colorectal cancer surgery.Methods:The clinical data of 60 patients with colorectal cancer admitted from March 2021 to November 2022 were collected,and the incidence of anastomotic fistula was statistically analyzed.According to whether anastomotic fistula occurred,the patients with anastomotic fistula were included in the occurrence group and the non-occurrence group.The serum CRP and PCT levels of the two groups were analyzed and compared,and the relationship between the serum CRP and PCT levels and the incidence of postoperative anastomotic fistula in colorectal cancer patients was analyzed.Results:The levels of serum PCT and CRP in the occurrence group were significantly higher than those in the non-occurrence group(P<0.05).After multiple Logistic regression analysis,serum PCT(β=0.859,OR=2.360,95%CI 1.103-5.050),CRP(β=5.781,OR=324.079,95%CI 2.573-40811.649)was associated with postoperative anastomotic fistula in colorectal cancer patients(P<0.05).Receiver operating curve(ROC)showed that serum PCT and CRP levels alone and in combination predicted the incidence of postoperative anastomotic fistula in colorectal cancer patients:the area under the curve(AUC)was>0.7.Conclusion:High levels of serum CRP and PCT are associated with postoperative anastomotic fistula in patients with colorectal cancer.
关键词
结直肠癌/吻合口瘘/C反应蛋白/降钙素原/预测价值Key words
colorectal cancer/Anastomotic fistula/C-reactive protein/Procalcitonin/Predictive value引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据