血清TGF-β1、Hcy水平与慢性心力衰竭患者比索洛尔治疗疗效的关系
Relationship between serum TGF-β1 and Hcy levels and the therapeutic effect of bisoprolol in patients with chronic heart failure
苏伟锋1
作者信息
- 1. 新郑华信民生医院心血管一病区,河南 郑州 451100
- 折叠
摘要
目的:探讨血清转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、同型半胱氨酸(Homocysteine,Hcy)水平与慢性心力衰竭(Chronic heart failure,CHF)患者比索洛尔治疗效果的关系.方法:选取 2020 年3 月～2022 年2 月医院接收的 113例CHF患者作为研究对象.患者均在本院接受比索洛尔治疗,观察并记录患者治疗6 m时的疗效并分组,患者治疗前均进行血清TGF-β1、Hcy水平检测,记录患者的一般资料,分析血清TGF-β1、Hcy水平与CHF患者比索洛尔治疗效果的关系.结果:113例CHF患者经评估,有 19 例治疗无效,94 例治疗有效;无效组血清TGF-β1、Hcy水平高于有效组,差异有统计学意义(P＜0.05).Logistic回归分析,结果显示,血清TGF-β1、Hcy过表达与CHF患者比索洛尔治疗无效有关(OR＞1,P＜0.05).绘制ROC曲线,结果显示,血清TGF-β1、Hcy单独及联合预测CHF患者比索洛尔治疗无效价值的曲AUC＞0.70,预测价值均理想,且以联合预测价值最佳.结论:血清TGF-β1、Hcy过表达与CHF患者比索洛尔治疗无效存在一定联系.
Abstract
Objective:To explore the relationship between serum Transforming growth factor-β1(TGF-β1)and Homocysteine(Hcy)levels and Chronic heart failure(Chronic heart failure).Relationship between treatment effect of bisoprolol in CHF patients.Methods:113 patients with CHF admitted to the hospital from March 2020 to February 2022 were selected as the study objects.All patients were treated with bisoprolol in our hospital,and the efficacy of the patients after 6 months of treatment was observed and recorded,and the patients were grouped into groups.Serum TGF-β1 and Hcy levels were detected before treatment,and general information of the patients was recorded,and the relationship between serum TGF-β1 and Hcy levels and the therapeutic effect of bisoprolol in CHF patients was analyzed.Results:113 patients with CHF,19 were ineffective and 94 were effective.The serum levels of TGF-β1 and Hcy in the ineffective group were higher than those in the effective group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that the overexpression of TGF-β1 and Hcy in CHF patients was associated with the ineffective treatment of bisoprolol(OR>1,P<0.05).ROC curve was drawn,and the results showed that the AUC of serum TGF-β1 and Hcy alone and combined in predicting the efficacy value of bisoprolol in CHF patients was greater than 0.70,and the predictive value was ideal,and the combined predictive value was the best.Conclusion:The overexpression of serum TGF-β1 and Hcy may be associated with the ineffectiveness of bisoprolol treatment in CHF patients.
关键词
慢性心力衰竭/比索洛尔/转化生长因子-β1/同型半胱氨酸Key words
chronic heart failure/Bisoprolol/Transforming growth factor-β1/Homocysteine引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据