Effects of laparoscopic surgery on the clinical efficacy and immune function and cytokines in patients with colorectal cancer
Objective:To analyze the clinical efficacy,immune function and cytokine effects of laparoscopic surgery in patients with colorectal cancer.Methods:Clinical data of 103 patients with colorectal cancer admitted to our hospital from May 2020 to November 2022 were retrospectively selected,and the patients were divided into control group(traditional radical resection of colorectal cancer,n=48)and observation group(laparoscopic surgery,n=55)according to different surgical protocols.After 1 month of treatment,the clinical efficacy of the two groups was analyzed,the immune function was measured by flow cytometry,and Growth differentiation factor 15(GDF-15),Recombinant human basic fibroblast growth factor(b-FGF)levels was detected by double antibody sandwich enzyme-linked immunosorbent assay.Results:The total curative effect of observation group was significantly higher than that of control group(P<0.05).Postoperative CD8+ decreased in both groups,while CD4+ and CD4+/CD8+ increased.CD8+ in observation group was significantly lower than that in control group,and CD4+ and CD4+/CD8+ were significantly higher than those in control group(P<0.05).The levels of GDF-15 and b-FGF in both groups decreased after operation,and the levels of GDF-15 and b-FGF in observation group were significantly lower than those in control group(P<0.05).Conclusion:Laparoscopic surgery for colorectal cancer can improve clinical efficacy,improve immune function and reduce cytokine levels.
NETL
NSTL
万方数据
维普
