首页|STS注射液联合营养治疗冠心病心绞痛的临床观察及对血清CK-MB、APN水平的影响

STS注射液联合营养治疗冠心病心绞痛的临床观察及对血清CK-MB、APN水平的影响

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目的:观察丹参酮ⅡA磺酸钠(Sulfotanshinone Sodium,STS)注射液联合营养治疗冠心病心绞痛的临床疗效.方法:选取 2020 年 1 月至 2022 年 10 月在我院治疗的冠心病心绞痛患者 122 例,按照随机数字表法分为对照组和观察组,各 61 例.对照组给予 60 mg STS注射液,观察组在对照组的基础上给予营养治疗.分析治疗 2 w后疗效和不良反应发生率,采用血液流变仪测定血流动力学指标,采用全自动生化仪测定血脂指标,采用酶联免疫法测定血清肌酸激酶同工酶(Creatine Kinase Isoenzyme-MB,CK-MB)及脂联素(Adiponectin,APN)水平并对比两组间差异.结果:观察组的治疗有效率明显高于对照组(P<0.05).治疗后,观察组的TC、TG、LDL-C、血浆黏度、全血粘度、纤维蛋白原及血细胞、CK-MB均显著低于对照组(P<0.05).观察组的APN显著高于对照组(P<0.05).结论:STS 注射液联合营养治疗冠心病心绞痛,能提高临床疗效,改善心功能和血流动力学,且不良反应少.
Clinical observation of STS injection combined with nutrition in the treatment of angina pectoris of coronary heart disease and its influence on serum CK-MB and APN levels
Objective:To observe the clinical efficacy of Sulfotanshinone Sodium(STS)injection combined with nutrition in the treatment of angina pectoris of coronary heart disease.Methods:A total of 122 patients with angina pectoris from CHD treated in our hospital from January 2020 to October 2022 were selected and divided into control group and observation group according to random number table method,with 61 cases in each group.The control group was given 60 mg STS injection,and the observation group was given nutritional treatment based on the control group.The therapeutic effect and incidence of adverse reactions after 2 weeks of treatment were analyzed.Hemodynamics indexes were determined by hemorheometer,blood lipid indexes were determined by automatic biochemical analyzer,and serum Creatine Kinase Isoenzyme-MB(CK-MB)was determined by enzyme-linked immunoassay.The levels of CK-MB and Adiponectin(APN)were compared between the two groups.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,TC,TG,LDL-C,plasma viscosity,whole blood viscosity,fibrinogen,blood cells and CK-MB in observation group were significantly lower than those in control group(P<0.05).The APN of observation group was significantly higher than that of control group(P<0.05).Conclusion:STS injection combined with nutrition in the treatment of angina pectoris of coronary heart disease can improve clinical efficacy,cardiac function and hemodynamics,with less adverse reactions.

STS injectionNutritional therapyCoronary heart diseaseAngina pectorisClinical observationCK-MBAPN

高洁、曾桂馨、刘闪闪

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南阳市中心医院心血管内科心律失常病区,河南 南阳 473000

南阳市中心医院综合ICU,河南 南阳 473000

STS注射液 营养治疗 冠心病 心绞痛 临床观察 CK-MB APN

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子:0.575
ISSN:1671-3885
年,卷(期):2024.46(2)
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