Application of 20 Hz repetitive transcranial magnetic stimulation in improving cognitive function in patients with Alzheimer's disease and its effect on serum inflammatory factors
Objective:To investigate the application of 20 HzrTMS in improving cognitive function in patients with AD and its effect on serum inflammatory factors.Methods:Ninty-six cases of AD patients admitted to our hospital from February 2021 to December 2022 were selected as research objects,and were divided into control group and observation group according to random number table method,with 48 cases in each group.Both groups were treated with conventional drugs,the control group was treated with false stimulation,and the observation group was treated with 20 Hz repeated transcranial magnetic stimulation.The changes of serum inflammatory factors,cognitive function,ERP and neuropsychological state before and after treatment were observed.Results:After treatment,the serum levels of TNF-α and IL-1β in observation group were significantly lower than those in control group(P<0.05).The amplitude of P300 in observation group was significantly higher than that in control group(P<0.05).The incubation period of P300 in the observation group was significantly shorter than that in the control group(P<0.05).The MoCA score of observation group was significantly higher than that of control group(P<0.05).The ADAS-cog and NPI scores of the observation group were significantly lower than those of the control group.Conclusion:The application of 20 Hz rTMS in AD patients can reduce the inflammatory response,improve ERP,cognitive function and neuropsychological state.
Twenty Hz repetitive transcranial magnetic stimulationAlzheimer's diseaseCognitive functionEvent-related potential