首页|20 Hz重复经颅磁刺激在改善阿尔茨海默症患者认知功能中的应用及其对血清炎性因子的影响

20 Hz重复经颅磁刺激在改善阿尔茨海默症患者认知功能中的应用及其对血清炎性因子的影响

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目的:探讨20 Hz重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)在改善阿尔茨海默症(Alzheimer's disease,AD)患者认知功能中的应用及其对血清炎性因子的影响.方法:选取2021年 2月至2022年12月期间我院收治的96例AD患者作为研究对象,按照随机数字表法分为对照组和观察组,各48 例.两组患者均使用常规药物治疗,对照组增加假性刺激治疗,观察组增加20 Hz重复经颅磁刺激治疗.观察两组治疗前后血清炎性因子水平、认知功能、事件相关电位(Event related potential,ERP)的变化情况以及神经心理状态.结果:治疗后,观察组血清肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-1β(Interleukin-1β,IL-1β)水平明显较对照组低(P<0.05);观察组P300 波幅明显高于对照组(P<0.05);观察组P300 潜伏期明显短于对照组(P<0.05);观察组蒙特利尔认知评估量表(Montreal cognitive assessment scale,MoCA)得分明显高于对照组(P<0.05);观察组阿尔茨海默病评定量表认知分表(Alzheimer's disease rating scale cognitive scale,ADAS-cog)、神经精神问卷(Neuropsychiatric Inventory,NPI)得分明显低于对照组.结论:20 Hz rTMS应用于AD患者可以降低机体的炎症反应,改善ERP情况、认知功能和神经心理状态.
Application of 20 Hz repetitive transcranial magnetic stimulation in improving cognitive function in patients with Alzheimer's disease and its effect on serum inflammatory factors
Objective:To investigate the application of 20 HzrTMS in improving cognitive function in patients with AD and its effect on serum inflammatory factors.Methods:Ninty-six cases of AD patients admitted to our hospital from February 2021 to December 2022 were selected as research objects,and were divided into control group and observation group according to random number table method,with 48 cases in each group.Both groups were treated with conventional drugs,the control group was treated with false stimulation,and the observation group was treated with 20 Hz repeated transcranial magnetic stimulation.The changes of serum inflammatory factors,cognitive function,ERP and neuropsychological state before and after treatment were observed.Results:After treatment,the serum levels of TNF-α and IL-1β in observation group were significantly lower than those in control group(P<0.05).The amplitude of P300 in observation group was significantly higher than that in control group(P<0.05).The incubation period of P300 in the observation group was significantly shorter than that in the control group(P<0.05).The MoCA score of observation group was significantly higher than that of control group(P<0.05).The ADAS-cog and NPI scores of the observation group were significantly lower than those of the control group.Conclusion:The application of 20 Hz rTMS in AD patients can reduce the inflammatory response,improve ERP,cognitive function and neuropsychological state.

Twenty Hz repetitive transcranial magnetic stimulationAlzheimer's diseaseCognitive functionEvent-related potential

付笑笑、刘欣欣、付美霞

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河南大学第一附属医院老年病科,河南 开封 475000

20 Hz重复经颅磁刺激 阿尔茨海默症 认知功能 事件相关电位

河南省医学科技攻关计划

LHGJ20210562

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子:0.575
ISSN:1671-3885
年,卷(期):2024.46(3)
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