Effect of minimally invasive surgery on levels of inflammatory factors and neurofactors in hypertensive cerebral hemorrhage
Objective:To explore the effect of minimally invasive procedure on hypertensive cerebral hemorrhage(HCH).Methods:A total of 80 patients with HCH in our hospital from January 2021 to January 2022 were randomly divided into two groups of 40 patients each.The control group underwent craniotomy to clean hematoma(CCH)and the study group underwent minimally invasive surgery.The clinical outcomes of the two groups were compared,and the preoperative and postoperative 1 m and 3 m nerve damage was assessed using the modified Rankin scale(mRS)and the National Institutes of Health Stroke Scale(NIHSS).The levels of procalcitonin(PCT),high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),glial fibrillary acidic protein(GFAP),and central nervous system-specific protein(S100β)were assessed by enzyme-linked immunoassay.Serum neuropeptide Y(NPY)level was measured by chemiluminescence.The incidence of postoperative complications was recorded.Results:The hematoma clearance rate was higher in the study group than in the control group,and the operative timet and blood loss were less than in the control group(P<0.05).One month and 3 months after surgery,the mRS score,NIHSS score,PCT,hs-CRP,TNF-α,NPY,GFAP,and S100β protein were lower in the study group than in the control group(P<0.05).The overall complication rate was lower in the study group than in the control group(P<0.05).Conclusion:The minimally invasive procedure is a safe and reliable treatment scheme for HCH,which is worth popularizing in clinics.
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