玻璃体腔注射康柏西普治疗糖尿病性黄斑水肿的效果及其对血清VEGF及SDF-1水平的影响
Effect of intravitreal injection of Conbercept in the treatment of diabetes macular edema and its influence on serum VEGF and SDF-1 levels
袁思佳 1张相冉 2王延武3
作者信息
- 1. 郑州市金水区总医院门诊眼科,河南 郑州 450000
- 2. 濮阳市人民医院眼科,河南 濮阳 457000
- 3. 郑州大学第二附属医院眼科,河南 郑州 450000
- 折叠
摘要
目的:探讨玻璃体腔注射康柏西普(商品名"朗沐")治疗糖尿病性黄斑水肿(Diabetes macular edema,DME)的效果及其对血清血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)及人基质细胞衍生因子1(Stromal Cell Derived Factor 1,SDF-1)水平的影响.方法:选取我科 2020 年 5 月至 2022 年 2 月期间 103 例DME患者,随机分为激光组和朗沐组.激光组 51 例给予眼底激光光凝治疗,朗沐组 52 例给予激光光凝联合朗沐治疗,对比两组患者视力水平、黄斑厚度、血管生长因子、不良反应.结果:治疗1、2、3 m后,朗沐组的最佳矫正视力(Best Corrected Visual Acuity,BCVA)测定值大于激光组(P＜0.05).治疗3 m后,朗沐组的黄斑中心凹厚度(Central Macular Thickness,CMT)、黄斑中心凹下脉络膜厚度(Subfoveal choroidal thickness,SFCT)均低于激光组(P＜0.05);朗沐组的血清VEGF、SDF-1水平均低于激光组(P＜0.05).两组的不良反应发生率无统计学差异.结论:玻璃体腔注射朗沐辅助治疗 DME 可有效抑制玻璃体内的血管生长,减轻黄斑水肿,从而改善患者的视力,安全性高.
Abstract
Objective:To investigate the effect of intravitreal injection of Conbercept(trade name:"Langmu")on diabetes macular edema(DME)and its effect on the levels of serum vascular endothelial growth factor(VEGF)and human stromal cell derived factor 1(SDF-1).Method:103 DME patients in our department from May 2020 to February 2022 were selected and randomly divided into laser group and Langmu group.51 patients in the laser group were received fundus laser photocoagulation treatment,while 52 patients in the Langmu group were received laser photocoagulation combined with Langmu treatment.The visual acuity,macular thickness,vascular growth factor,and adverse reactions of the two groups were compared.Result:After 1,2,and 3 months of treatment,the best corrected visual acuity(BCVA)in the Langmu group was higher than that in the laser group(P<0.05).After 3 months of treatment,the Central Macular Thickness(CMT)and Subfoveal Choroidal Thickness(SFCT)of the Langmu group were lower than those of the laser group(P<0.05);The serum levels of VEGF and SDF-1 in the Langmu group were lower than those in the laser group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion:Intravitreous injection of Langmu as an adjuvant therapy for DME can effectively inhibit vascular growth in the vitreous body,reduce macular edema,and improve patients'vision with high safety.
关键词
DME/玻璃体腔/康柏西普/视力/黄斑厚度Key words
DME/Vitreous cavity/Conbercept/vision/Macular thickness引用本文复制引用
出版年
2024
NETL
NSTL
万方数据