Effects of carvedilol combined with perindopril on patients with dilated cardiomyopathy
Objective:To observe the efficacy of carvedilol combined with perindopril in the treatment of patients with dilated cardiomyopathy(DCM).Methods:All 64 cases of DCM received in our hospital from November 2020 to September 2022 were divided into conventional and experimental groups(n=32)according to the random number table method.The conventional group was given perindopril(oral,initial dose 2 mg·d-1,target dose 8 mg·d-1),and the experimental group was given carvedilol(Oral,initial dose of 2.5 mg·time-1,2 times·d-1,maximum dose of 30 mg·d-1)combined with perindopril(the dosage was the same as that of the conventional group).After 6 months of treatment,the efficacy,cardiac function grade(New York Heart Association,NYHA),and adverse reactions were compared between the two groups.Before and after treatment,color Doppler ultrasound was used to measure left ventricular short axis reduced rate(FS),ejection fraction(EF),cardiac index(CI),left atrial diameter(LAD),left ventricular posterior wall thickness(LVPW),left ventricular end-diastolic diameter(LVDD),and end-diastolic ventricular septal thickness(IVS).Radioimmunoassay was used to measure the level of endothelin-1(ET-1),latex immunoassay was used to measure the level of highly sensitive C-reactive protein(hs-CRP),oxidation-reduction method was used to measure the level of nitric oxide(NO),electrochemical immunoassay was used to measure the level of B-type natriuretic peptide(BNP).Results:The total effective rate of the experimental group(96.88%)was higher than that of the conventional group(75.00%)(P<0.05).After treatment,the NYHA grade decreased significantly in the experimental group(P<0.05).After treatment,the levels of LAD,LVPW,LVDD,serum levels of ET-1,hs-CRP,and BNP in the experimental group were lower than those in the conventional group,while IVS,EF,FS,CI,and the serum level of NO were higher than those in the conventional group(P<0.05).There was no difference in the total incidence of adverse reactions between the experimental group(9.38%)and the conventional group(12.5%)(P>0.05).Conclusion:Carvedilol combined with perindopril is effective in the treatment of DCM,which can reduce the inflammatory response,improve endothelial function,cardiac remodeling,and cardiac function,and has certain safety.
CarvedilolPerindoprilDilated cardiomyopathyCardiac function
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