Effects of Ezetimibe combined with Bisoprolol on cardiac function and inflammatory factors in patients with coronary heart disease after interventional therapy
Objective:To investigate the effects of ezetimibe combined with Bisoprolol on cardiac function and inflammatory factors in patients with coronary heart disease after interventional therapy.Methods:150 patients with coronary artery disease who underwent interventional therapy in our hospital from March 2020 to March 2023 were randomized and digitally divided into the control group and the combined group,75 cases in each group.The control group was treated with bisoprolol,and the combined group was treated with ezetimibe combined with bisoprolol.The clinical efficacy,cardiac function indexes,lipid levels[High-density lipoprotein-cholesterol(HDL-C),Low-density lipoprotein cholesterol(LDL-C),Triacylglycerol(Triacylglycerol(TG),Total cholesterol(TC)],serum cytokines levels,and adverse reactions were compared between the two groups before and after 4 weeks of treatment.Results:The total clinical effective rate of the combined group was higher than that of the control group(P<0.05);the cardiac function indexes of the combined group were higher than those of the control group after 4 weeks of treatment(P<0.05);the HDL-C level of the combined group was higher than that of the control group,and the levels of LDL-C,TG,and TC were lower than those of the control group after 4 weeks of treatment(P<0.05);and the serum cytokine levels of the combined group were lower than those of the control group after 4 weeks of treatment(P<0.05);the difference in the total incidence of adverse reactions between the two groups was not statistically significant.Conclusion:Ezetimibe combined with Bisoprolol is effective in the treatment of patients with coronary artery disease after interventional therapy,which can effectively improve cardiac function,regulate lipid levels,relieve inflammation and do not significantly increase adverse reactions.
EzetimibeBisoprololCoronary heart diseaseCardiac function
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