Effects of mild hypothermia therapy combined with edaravone in the treatment of children with severe cranial injury
Objective:To investigate the clinical efficacy of mild hypothermia therapy combined with edaravone in the treatment of children with severe craniocerebral injury(SCCI),and its effects on neurological function,hemorheology,inflammatory factors,and prognosis.Methods:Ninety-eight children with SCCI admitted to Nanyang First People's Hospital from January 2019 to December 2022 were selected as the study objects.The children were divided into a routine group and a combination group(n=49)by random number table method,they received symptomatic rescue treatment and symptomatic rescue treatment + mild hypothermia combined with edaravone,respectively.After 2 weeks of treatment,the clinical efficacy and adverse reactions were compared between the two groups,National Institutes of Health stroke scale(NIHSS)was used to estimate the neurological function,Glasgow outcome scale(GOS)was used to estimate the prognosis and recovery status,automatic blood Rheometer was used to detect the hemorheological indicators(plasma viscosity,whole blood low tangential viscosity,whole blood high tangential viscosity,erythrocyte sedimentation rate),enzyme-linked immunosorbent assay was used to measure the inflammatory factors,including hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),ubiquitin C-terminal hydrolyse-L1(UCH-L1),ficolin 3(FCN3).Results:After 2 weeks of treatment,the total effective rate of the combination group(93.88%)was higher than that of the routine group(79.59%)(P<0.05).The NIHSS score in the combination group was lower than that in the routine group,GOS score was higher than that in the routine group(P<0.05).Plasma viscosity,whole blood low shear viscosity,whole blood high shear viscosity,erythrocyte sedimentation rate,and serum levels of hs-CRP,IL-6,and UCH-L1 in the combination group were significantly lower than those in the routine group,and FCN3 level was significantly higher than that in the routine group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Mild hypothermia therapy combined with edaravone is effective in the treatment of children with SCCI,which can effectively improve hemorheology,reduce nerve damage,inhibit inflammatory response,and has good safety.
Mild hypothermia therapyEdaravoneSevere craniocerebral injuryCranial nerve function
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