Efficacy of Budesonide,Glycopyrronium Bromide,and Formoterol Fumarate inhalation aerosol combined with azithromycin in the treatment of patients with chronic obstructive pulmonary disease complicated with pneumonia and its impact on serum sTREM-1 and PCT l
Objective:To explore the efficacy of Budesonide,Glycopyrronium Bromide,and Formoterol Fumarate inhalation aerosol combined with azithromycin in the treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with pneumonia.Methods:One hundred and six patients with chronic obstructive pulmonary disease complicated with pneumonia admitted to our hospital from December 2020 to December 2022 were selected and randomly divided into a control group and a combination group,with 53 patients in each group.The control group was treated with azithromycin 0.5 g by intravenous drip,once a day,while the combination group was treated with Budesonide,Glycopyrronium Bromide,and Formoterol Fumarate inhalation aerosol(2 puffs per session,2 times a day)combined with azithromycin.After 10 days of treatment,the clinical efficacy,improvement time of clinical symptoms,lung function,serum-related indicators,and adverse reactions between the two groups were analyzed.The lung function indicators were measured using a lung function detector.Enzyme-linked immunosorbent assay and immunoluminescence assay were used to detect the levels of serum-related indicators.Results:The total clinical effective rate of the combined group is higher than that of the control group(P<0.05).After treatment,the clinical symptom improvement time of the combination group was shorter than that of the control group,and the lung function indicators were higher than those of the control group,while the serum-related indicators were lower than those of the control group(P<0.05).Also,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Budesonide,Glycopyrronium Bromide,Formoterol Fumarate inhalation aerosol,and azithromycin in the treatment of chronic obstructive pulmonary disease with pneumonia can improve clinical efficacy,promote symptom improvement,alleviate inflammatory reactions,improve lung function,and have high safety.
Budesonide,Glycopyrronium Bromide and Formoterol Fumarate inhalation aerosolAzithromycinChronic obstructive pulmonary disease with pneumoniaCurative effect
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