Application value of Ganshuang Granule combined with Tenofovir dipifuroxide fumarate in improving liver function and alleviating liver fibrosis in patients with compensated hepatitis B cirrhosis
Objective:To analyze the effect of Ganshuang Granule combined with Tenofovir dipifurate fumarate in the treatment of compensated hepatitis B cirrhosis and its influence on liver function and degree of liver fibrosis.Methods:A total of 94 patients with compensated hepatitis B cirrhosis admitted to our hospital from October 2020 to October 2022 were selected as study subjects and grouped into two groups randomly.47 cases in the basic group were treated with tenofovir dipifurate fumarate,and on this basis 48 cases in the experimental group were treated with Ganshuang granules.After 6 months,the clinical efficacy,liver function,liver fibrosis degree and adverse reactions were compared between the two groups.Results:The total effective rate of the experimental group was higher than that of the basic group(P<0.05).After treatment,the levels of Alanine transferase(ALT),Aspartate transferase(AST)and Total bilirubin(TBIL)in experimental group were lower than those in basic group(P<0.05);After treatment,levels of Hyaluronic acid(HA),Type Ⅲ procollagen(PcⅢ),Type Ⅳ procollagen(Ⅳ-C)and laminin in the experimental group were lower than those in the basic group(P<0.05).There are no marked differences in the incidences of adverse reactions between the two groups.Conclusion:Ganshuang Granule combined with Tenofovir dipifurate fumarate can effectively protect the liver function of patients with hepatitis B cirrhosis in compensatory stage,improve the degree of liver fibrosis,improve the therapeutic effect,and have high safety.
Ganshuang GranuleTenofovir dipifurate fumarateCompensatory hepatitis B cirrhosisLiver functionDegree of liver fibrosis
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