Analysis of the therapeutic effect of lung surface active substance-assisted mechanical ventilation in preterm infants with respiratory distress syndrome
Objective:To investigate the clinical efficacy,pulmonary function and safety of pulmonary surfactant(PS)assisted mechanical ventilation in the treatment of premature respiratory distress syndrome(NRDS).Methods:Sixty-two children with NRDS admitted to our hospital from May 2020 to September 2023 were selected for the study,and were divided into 30 cases in the control group(mechanical ventilation on the basis of conventional treatment)and 32 cases in the observation group(combined with PS treatment on the basis of the control group)according to the different treatment plans.We compared the clinical efficacy,changes in lung function[Dynamic lung compliance(CD),Oxygenation index(PaO2/FiO2),Inspiratory resistance(RAWO)]indexes,length of hospitalisation,duration of ventilator use,and complication rate of children with NRDS in the two groups before and after treatment.Results:After treatment,the total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,CD and PaO2/FiO2 increased significantly and RAWO decreased significantly in both groups,and CD and PaO2/FiO2 were significantly higher in the observation group than in the control group,and RAWO was significantly lower than in the control group(P<0.05).After treatment,the average hospitalisation time and average ventilator use time of the observation group were significantly shorter than those of the control group,and the total incidence of complications was significantly lower than that of the control group(P<0.05).Conclusion:PS-assisted mechanical ventilation for the treatment of NRDS can promote the recovery of children's lung function,improve clinical efficacy,and has a high degree of safety.
Lung surface active substancesmechanical ventilationpreterm infantsrespiratory distressclinical efficacylung functionsafety
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