首页|血清HE4水平与子宫内膜癌患者临床病理特征的相关性

血清HE4水平与子宫内膜癌患者临床病理特征的相关性

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目的:分析血清人附睾分泌蛋白4(Human epididymis protein 4,HE4)水平和子宫内膜癌患者临床病理特征的相关性.方法:回顾性分析 2019 年 1 月至 2022 年 6 月医院收治的 120 例子宫内膜癌患者临床资料.所有患者均实施子宫全切术治疗,收集患者的临床病理特征资料,检测所有患者HE4 水平,分析血清HE4 水平与子宫内膜癌患者临床病理特征的相关性.结果:120例子宫内膜癌患者中,病理类型:子宫内膜样腺癌46 例、子宫内膜样透明细胞癌36例、子宫内膜样鳞癌38例;淋巴结转移:发生35例、未发生85例;肌层浸润深度:＞1/2 肌层40 例、≤1/2 肌层 80 例;TNM分期:Ⅰ期 22 例、Ⅱ期 43 例、Ⅲ期 55 例.病灶所处部位:子宫底 55 例、子宫角37例、宫颈管 28例.不同病理类型、TNM分期、病灶所处部位患者的血清HE4水平比较,差异无统计学意义;肌层浸润深度＞1/2 肌层患者的血清 HE4 水平高于肌层浸润深度≤1/2 肌层的患者,发生淋巴结转移患者的血清HE4 水平较未发生淋巴结转移的患者明显增加(P＜0.05).经Logistic回归显示,血清HE4 水平升高是子宫内膜癌患者肌层浸润深度＞1/2肌层的风险因子(OR＞1,P＜0.05);血清HE4 水平升高是子宫内膜癌患者发生淋巴结转移的风险因子(OR＞1,P＜0.05).结论:血清HE4水平升高增加可加剧肌层浸润深度,促使子宫内膜癌患者发生淋巴结转移.
Correlation between serum HE4 level and clinicopathological features of patients with endometrial cancer
Objective:To analyze the correlation between serum levels of Human epididymis protein 4(HE4)and clinicopathological features in patients with endometrial cancer.Methods:Clinical data of 120 patients with endometrial carcinoma admitted to hospital from January 2019 to June 2022 were retrospectively analyzed.All patients were treated with total hysterectomy.Clinicopathological data of patients were collected,and the level of HE4 in all patients was detected,and the correlation between serum HE4 level and clinicopathological features of patients with endometrial cancer was analyzed.Results:Among 120 cases of endometrial carcinoma,46 cases were endometrioid adenocarcinoma,36 cases were endometrioid clear cell carcinoma and 38 cases were endometrioid squamous cell carcinoma.Lymph node metastasis occurred in 35 cases and not in 85 cases.Infiltration depth of muscle layer:>1/2 muscle layer 40 cases,≤1/2 muscle layer 80 cases;TNM stages:Stage I(22 cases),stage Ⅱ(43 cases),stage Ⅲ(55 cases).The lesions were located in 55 cases of uterine floor,37 cases of uterine horn and 28 cases of cervical canal.There was no significant difference in serum HE4 level among patients with different pathological types,TNM stages and lesion locations.The serum HE4 level in patients with myographic infiltration depth>1/2 was higher than that in patients with myographic infiltration depth≤1/2,and the serum HE4 level in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(P<0.05).Logistic regression showed that the increase of serum HE4 level was a risk factor for the depth of muscle invasion>1/2 muscle layer in patients with endometrial cancer(OR>1,P<0.05).Elevated serum HE4 level was a risk factor for lymph node metastasis in patients with endometrial cancer(OR>1,P<0.05).Conclusion:The increase of serum HE4 level can aggravate the depth of myographic infiltration and promote lymph node metastasis in patients with endometrial carcinoma.

Endometrial cancerSerum human epididymal secretory protein 4Clinicopathological featuresCorrelation

王云华

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光山县人民医院妇科,河南 信阳 465450

子宫内膜癌 血清人附睾分泌蛋白4 临床病理特征 相关性

2024

四川生理科学杂志
四川省生理科学会

四川生理科学杂志

影响因子：0.575
ISSN：1671-3885
年,卷(期)：2024.46(3)
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