Analysis of the value of Hcy,CTnI and BNP in evaluating the condition and prognosis of hypertensive patients with ejection fraction preserving heart failure
Objective:To explore the meaning of serum Homocysteine(Hcy),Cardiac Troponin I(CTnI)and Brain Natriuretic Peptide(BNP)in the assessment of the condition and prognosis of hypertensive Heart Failure with Preserved LV Ejection Fraction(HF-PEF).Methods:116 patients with hypertension combined with HF-PEF treated from January 2020 to May 2022 were selected as the observation group,and 102 healthy subjects were selected as the control group.According to different cardiac function grades,the observation group was divided into grade Ⅱ,grade Ⅲ and grade Ⅳ.According to the occurrence of Major Adverse Cardiovascular Events(MACE)during hospitalization and within six months after discharge,the observation group was further divided into MACE group and non-MACE group.The serum levels of Hcy,CTnI and BNP were analyzed and compared between the two groups.The serum levels of Hcy,CTnI and BNP were analyzed and compared in the observation group with different cardiac function grades.To analyze the significance of serum Hcy,CTnI and BNP in prognostic evaluation of hypertension complicated with HF-PEF.Results:The levels of Hcy,CTnI and BNP in observation group were significantly higher than those in control group(P<0.05).The levels of serum Hcy,CTnI and BNP in patients with different cardiac function grades were grade Ⅱ<grade Ⅲ<grade Ⅳ(P<0.05).There were no significant differences in age and sex between MACE group and non-MACE group,but there were significant differences in cardiac function grade,serum Hcy,CTnI and BNP levels(P<0.05).Multiple Logistic regression analysis showed that cardiac function grading,Hcy,CTnI and BNP were all influential factors for MACE in patients with hypertension combined with HF-PEF.Conclusion:Serum Hcy,CTnI and BNP can effectively evaluate the progression and prognosis of hypertension combined with HF-PEF,which has certain guiding significance for early diagnosis and treatment.
HcyCTnIBNPHypertension combined with ejection fraction preserving heart failurePrognosis assessment
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